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MSP13

Membrane Scaffold Protein 1D1 BTN

Name: Membrane Scaffold Protein 1D1 BTN
Brand: SIGMA

recombinant, expressed in E. coli, Biotin labeled

別名:

1D1 BTN Protein, Membrane Protein Scaffold, Scaffold Protein 1D1 BTN

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あなたへ/カタログ番号	在庫状況	単価

この商品について

NACRES:

NA.26

UNSPSC Code:

12352200

Form:

buffered aqueous solution

Assay:

≥90% (SDS-GE)

Recombinant:

expressed in E. coli

Mol wt:

26,900.1 Da by calculation (without biotin)

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特性

recombinant

expressed in E. coli

Quality Segment

200

assay

≥90% (SDS-GE)

form

buffered aqueous solution

mol wt

26,900.1 Da by calculation (without biotin)

solubility

water: soluble

shipped in

ambient

storage temp.

−20°C

詳細

General description

Research area: Cell Struc

The first MSP, MSP1, was engineered with its sequence based on the sequence of A-1, but without the globular N-terminal domain of native A-1. The Membrane Scaffold Protein 1D1 (MSP1D1) variant of MSP1 deletes the first 11 amino acids in the Helix 1 portion (referred to as “H0.5” in the accompanying figure) of the original MSP1 sequence. The MSP1D1 BTN variant of MSP1D1 features an enzymatically biotinylated additional 20-amino acid sequence at the C-terminus of MSP1D1.
Nanodisc technology is an approach to render membrane proteins soluble in aqueous solutions in a native-like bilayer environment, where the membrane proteins remain stable and active. The Nanodisc concept is derived from high density lipoprotein (HDL) particles and their primary protein component, apolipoprotein. The Nanodisc is a non-covalent structure of phospholipid bilayer and membrane scaffold protein (MSP), a genetically engineered protein, which mimics the function of Apolipoprotein A-1 (ApoA-1)

Application

For guidelines on the use of this and other MSP′s to prepare Nanodiscs, please visit our Protocols for Membrane Scaffold Proteins and Nanodisc Formation page.

Biochem/physiol Actions

Scaffold proteins are vital for imparting specificity to the mitogen-activated protein kinase (MAPK) pathway, which is necessary for normal cellular functions and development. They assist in regulating the localization of MAPK components, enabling precise modulation of cellular responses while preserving overall MAPK activity.

Legal Information

Nanodisc technology, and many of its uses, are covered by the following patents held by the University of Illinois.

7,691,414 Membrane scaffold proteins
7,662,410 Membrane scaffold proteins and embedded membrane proteins
7,622,437 Tissue factor compositions and methods
7,592,008 Membrane scaffold proteins
7,575,763 Membrane scaffold proteins and tethered membrane proteins
7,083,958 Membrane scaffold proteins
7,048,949 Membrane scaffold proteins

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当該品目	MSP03	MSP04	MSP02
Sigma-Aldrich MSP13 Membrane Scaffold Protein 1D1 BTN	Sigma-Aldrich MSP03 Membrane Scaffold Protein 1D1(-)	Sigma-Aldrich MSP04 Membrane Scaffold Protein 1E1D1	Sigma-Aldrich MSP02 Membrane Scaffold Protein 1D1 D73C
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli
assay ≥90% (SDS-GE)	assay ≥90% (SDS-GE)	assay ≥90% (SDS-GE)	assay ≥90% (SDS-GE)
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution
mol wt 26,900.1 Da by calculation (without biotin)	mol wt 22,043.9 Da	mol wt -	mol wt -
shipped in ambient	shipped in ambient	shipped in ambient	shipped in ambient
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

保管分類

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

MSP13-BULK: + MSP13-VAR: + MSP13-5MG:

jan

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