MAK202

Cathepsin S Inhibitor Screening Kit

Sufficient for 100 Fluorometric tests

• 別名: CTSS Inhibitor Assay Kit
• UNSPSCコード: 12352200

特性

• 検出方法: fluorometric
• 関連疾患: endocrinological disorders, diabetes; cardiovascular diseases; cancer
• 保管温度: −20°C
• 遺伝子情報: human ... CTSS(1520) ; mouse ... CTSS(13040) ; rat ... CTSS(50654)

詳細

詳細

Cathepsin S (CTSS; EC 3.4.22.27) is a lysosomal cysteine proteinase involved in the degradation of proteins to peptides required for the presentation of MHC class II molecules.1 It is associated with pathological conditions such as atherosclerosis, coronary heart disease, cancer, and insulin resistance.

適合性

Suitable for the screening of inhibitors of Cathepsin S.

原理

The Cathepsin S Inhibitor Screening Kit is a simple assay for screening potential inhibitors of CTSS. CTSS activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λ_ex = 400/ λ_em = 505 nm), proportional to the enzymatic activity present.

キットの構成要素のみ

• CTSS Reaction Buffer
• Cathepsin S, human
• CTSS Substrate, Z-VVR-AFC, 10 mM
• CTSS Inhibitor Z-FF-FMK, 1 mM

安全性情報

• 保管分類コード: 10 - Combustible liquids