由来生物
goat
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
lyophilized powder
化学種の反応性
human
テクニック
indirect ELISA: 0.5-1.0 μg/mL
neutralization: suitable
western blot: 0.1-0.2 μg/mL
UniProtアクセッション番号
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... IGFBP4(3487)
詳細
Insulin-like growth factor binding protein-4 (IGFBP-4) is a 26kD (approx.) protein expressed highly in non-paranchymal cells of the liver. IGFBP-4 is also expressed in spleen, liver, lung, kidney, adrenal, testis, heart, brain cortex, stomach and hypothalamus. It has a pivotal role in protecting cells from overstimulation caused by IGFs or towards activating the alternate transmembrane signaling pathways that are inhibited by IGF exposure. Anti-Insulin-like Growth Factor Binding Protein 4(IGFBP-4) antibody can be used in western blotting. Goat anti-IGFBP-4 antibody reacts specifically with recombinant human IGFBP-4. The product has shown no cross-reactivity for recombinant human IGFBP-1, recombinant human IGFBP-2, recombinant human IGFBP-3, recombinant human IGFBP-5 and recombinant human IGFBP-6.
特異性
By immunoblotting and ELISA, the antibody show no cross-reactivity with recombinant human IGFBP-2, recombinant human IGFBP-3, recombinant human IGFBP-1, recombinant human IGFBP-5, and recombinant human IGFBP-6.
免疫原
purified, NSO-derived, recombinant human insulin-like growth factor binding protein 4.
アプリケーション
Anti-Insulin-like Growth Factor Binding Protein-4(IGFBP-4) antibody can be used in neutralization and indirect ELISA.
物理的形状
凍結乾燥品(PBS溶液, 5%トレハロース含有, 0.2 μmフィルター滅菌済み)。
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試験成績書(COA)
製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Molecular endocrinology (Baltimore, Md.), 4(10), 1451-1458 (1990-10-01)
cDNA clones encoding a novel insulin-like growth factor-binding protein (IGFBP) purified from rat serum and human bone cell-conditioned medium have been isolated from rat liver and human placenta, liver, and ovary cDNA libraries. The deduced amino acid sequences of the
Insulin-like growth factors and their binding proteins: biological actions.
Endocrine reviews, 16(1), 3-34 (1995-02-01)
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