由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
分子量
antigen ~80 kDa
化学種の反応性
human
濃度
~1.0 mg/mL
テクニック
western blot: 0.5-1 μg/mL
UniProtアクセッション番号
アプリケーション
research pathology
輸送温度
dry ice
保管温度
−20°C
遺伝子情報
human ... IKBKE(9641)
詳細
IKK-epsilon/IKK-I belongs to IκB kinase complex and express mainly in immune cells. IKK-I express in response to proinflammatory cytokines such as tumor necrosis factor-α, IL-, IL-6 and stimulate NF-κB activation, hence referred as inducible IκB kinase . Polyclonal anti-IKK epsilon/IKK-I c-terminal antibody can be used in immunoblotting to detect human IKK epsilon/IKK-I. Anti-IKK epsilon/IKK-I antibodies can react specifically with human IKK epsilon/IKK-I and show no cross reactivity with IKK α, IKK β and IKK γ.
特異性
抗体は、IKKα、IKKβ、IKKγとの交差反応性は示しません。
免疫原
Synthetic peptide corresponding to amino acids 701-716 of human IKK-epsilon/IKK-I conjugated to KLH.
アプリケーション
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Polyclonal anti-IKK epsilon/IKK-I c-terminal antibody can be used in immunoprecipitation and western blot.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
PBS溶液(0.02%アジ化ナトリウム含有)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
I4907-100UG:
I4907-VAR:
I4907-BULK:
I4907-100UG-PW:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Suhu Liu et al.
Blood advances, 2(23), 3428-3442 (2018-12-07)
To identify novel therapeutic targets in acute myeloid leukemia (AML), we examined kinase expression patterns in primary AML samples. We found that the serine/threonine kinase IKBKE, a noncanonical IkB kinase, is expressed at higher levels in myeloid leukemia cells compared
T Shimada et al.
International immunology, 11(8), 1357-1362 (1999-07-28)
Using the suppression subtractive hybridization technique, we isolated a novel kinase, IKK-i, whose message is drastically induced by lipopolysaccharide (LPS) in the mouse macrophage cell line RAW264. 7. The predicted protein contains the kinase domain in its N-terminus, which shares
R T Peters et al.
Molecular cell, 5(3), 513-522 (2000-07-06)
Here we report the identification of a novel PMA-inducible IkappaB kinase complex, distinct from the well-characterized high-molecular weight IkappaB kinase complex containing IKKalpha, IKKbeta, and IKKgamma. We have characterized one kinase from this complex, which we designate IKKepsilon. Although recombinant
Jian-Ping Guo et al.
The Journal of biological chemistry, 285(6), 3676-3684 (2009-11-27)
IKKepsilon has recently been identified as a breast cancer oncogene. Elevated levels of IKKepsilon are associated with cell survival and growth. Here, we show that IKKepsilon interacts with and phosphorylates estrogen receptor alpha (ERalpha) on serine 167 in vitro and
Israel Cañadas et al.
Nature medicine, 24(8), 1143-1150 (2018-07-25)
Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely defined. Here, we identify a subclass of endogenous retroviruses (ERVs) that
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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