HPA018166

抗RRP1抗体 ウサギ宿主抗体

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2

• 別名: Anti-Novel nuclear protein 1, Anti-Nucleolar protein Nop52, Anti-Protein NNP-1, Anti-RRP1-like protein, Anti-Ribosomal RNA processing protein 1 homolog A
• UNSPSCコード: 12352203
• Human Protein Atlas Number: HPA018166
• NACRES: NA.43

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 製品種目: Prestige Antibodies^® Powered by Atlas Antibodies
• 形状: buffered aqueous glycerol solution
• 化学種の反応性: human
• テクニック: immunoblotting: 0.04-0.4 μg/mL; immunofluorescence: 0.25-2 μg/mL; immunohistochemistry: 1:200-1:500
• 免疫原配列: NLKFIDPFCRIAARTKDSLVLNNITRGIFETIVEQAPLAIEDLLNELDTQDEEVASDSDESSEGGERGDALSQKRSEKPPA
• UniProtアクセッション番号: P56182
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... RRP1(8568)

詳細

詳細

The gene RRP1 (ribosomal RNA processing protein-1 homolog A) has been mapped to human chromosome 21q22.3. The protein is a human homologue of the yeast ribosomal RNA processing protein RRP1. The protein has been localized to the nucleoli and at the periphery of the chromosomes.

免疫原

リボソームRNAプロセシングタンパク質1ホモログAのPrEST(protein epitope signature tag)抗原リコンビナントタンパク質。

アプリケーション

Prestige抗体^®は、Human Proteome Resource(HPR)プロジェクト(www.proteinatlas.org)によって開発・実証されたAtlas抗体です。抗体はすべて、数百の正常組織・疾病組織に対する免疫組織染色試験を行っています。これらの染色画像はHuman Protein Atlas(HPA)サイトで[Image Gallery]リンクをクリックするとご覧いただけます。さらに、ほとんどのPrestige抗体はプロテインアレイおよびウェスタンブロッティングの試験を行っています。試験のプロトコールおよびPrestige抗体、HPAに関する情報はsigma.com/prestigeをご覧ください。

生物化学的／生理学的作用

In nucleoli, ribosomal RNA processing protein-1 homolog A (RRP1) is excluded from the rRNA transcription sites, which accumulates in the granular external domain and mainly co-localizes with nucleolar proteins such as B23 which are involved in late processing step. The perinuclear bodies sequentially recruit fibrillarin, nucleoli and RRP1 together with B23 during formation of the nucleolus at the end of mitosis. p32, fibrillarin and RRP1 play key roles in the separation of pre-90S particle into pre-40S and pre-60S particles. RRP1 is also involved in the cleavage at site 2 in internal transcribed space1 of pre-rRNAs at early stages of human ribosome biogenesis. Together the above two events are essential to produce the small and large ribosomal subunits in human cells.

特徴および利点

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

関連事項

Corresponding Antigen APREST73884

物理的形状

PBS溶液(pH 7.2, 40%グリセロールおよび0.02%アジ化ナトリウム含有)。

法的情報

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable