HPA014028

Anti-TMEM204 antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• 別名: Anti-Claudin-like protein 24, Anti-Transmembrane protein 204
• UNSPSCコード: 12352203
• Human Protein Atlas Number: HPA014028
• NACRES: NA.43

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 製品種目: Prestige Antibodies^® Powered by Atlas Antibodies
• 形状: buffered aqueous glycerol solution
• 化学種の反応性: human
• 強化検証: recombinant expression; Learn more about Antibody Enhanced Validation
• テクニック: immunoblotting: 0.04-0.4 μg/mL; immunohistochemistry: 1:50-1:200
• 免疫原配列: HKREDCMAPRVIVISRSLTARFRRGLDNDYVESPC
• UniProtアクセッション番号: Q9BSN7
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TMEM204(79652)

詳細

詳細

The gene TMEM204 (transmembrane protein 204) encodes a four transmembrane spanning protein that is commonly called CLP24 (claudin-like protein of 24kDa). It is found to be homologous to myelin protein 22/epithelial membrane protein 1/claudin family of cell junction proteins. These homologous proteins modulate paracellular permeability. The encoded protein contains a protein-protein interaction domain at the C-terminus. It is abundantly expressed in lung, heart, kidney and placental tissues. It localizes to cell-cell junctions and is found to exist along with the β-catenin adherens junction-associated protein. It does not co-exist with tight junctions.

免疫原

膜貫通タンパク質204のPrEST(protein epitope signature tag)抗原リコンビナントタンパク質。

アプリケーション

Prestige抗体^®は、Human Proteome Resource(HPR)プロジェクト(www.proteinatlas.org)によって開発・実証されたAtlas抗体です。抗体はすべて、数百の正常組織・疾病組織に対する免疫組織染色試験を行っています。これらの染色画像はHuman Protein Atlas(HPA)サイトで[Image Gallery]リンクをクリックするとご覧いただけます。さらに、ほとんどのPrestige抗体はプロテインアレイおよびウェスタンブロッティングの試験を行っています。試験のプロトコールおよびPrestige抗体、HPAに関する情報はsigma.com/prestigeをご覧ください。

生物化学的／生理学的作用

The gene TMEM204 (transmembrane protein 204) encodes a tetraspan adherens junction protein that is hypoxically regulated. It may be involved in the regulation of cell adhesion, paracellular permeability and angiogenesis. Over expression of this protein leads to reduced adhesion between cells and variation of its junctional barrier function.

特徴および利点

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

関連事項

Corresponding Antigen APREST72616

物理的形状

PBS溶液(pH 7.2, 40%グリセロールおよび0.02%アジ化ナトリウム含有)。

法的情報

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)