HPA006870

Anti-SMG1 antibody produced in rabbit

Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

• 別名: 抗Q6P435抗体
• UNSPSCコード: 12352203
• Human Protein Atlas Number: HPA006870
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 製品種目: Prestige Antibodies^® Powered by Atlas Antibodies
• 形状: buffered aqueous glycerol solution
• 化学種の反応性: human
• テクニック: immunohistochemistry: 1:50- 1:200
• 免疫原配列: PGSRLSSGGTNYSRSWNDWQPRTDSASADPGNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSVN
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... SMG1P5(595101)

詳細

特異性

Note: The Ensemble Gene ID has changed from ENSG00000205534 in the 46:36 release of the database to ENSG00000183604 in the 48:36 release of the database.

免疫原

Putative uncharacterized SMG1-like protein

アプリケーション

Prestige抗体^®は、Human Proteome Resorce(HPR)　プロジェクト (www.proteinatlas.org)で開発されたAtlas抗体です。Prestige抗体はすべて、数百の正常組織・疾病組織に対する免疫組織染色試験を行っています。これらの染色画像はHuman Protein Atlas (HPA)サイトで[Image Gallery]リンクをクリックするとご覧いただけます。Prestige抗体はプロテインアレイおよびウェスタンブロッティングの試験も行っています。Prestige AntibodiesおよびHPAに関するこれらの プロトコ-ル やその他の有用な情報については、 sigma.com/prestigeをご覧下さい。

生物化学的／生理学的作用

SMG1 (Suppressor with morphogenetic effect on genitalia family member) is a PI3K-related kinase belonging to the phosphatidylinositol 3-kinase-related kinase family. Its major activity is nonsense-mediated mRNA decay (NMD). In the initial stage of NMD, it phosphorylates the UPF1 helicase. SMG1 also acts as a tumor suppressor gene in tumorigenesis. In hepatocellular carcinoma (HCC), SMG1 expression is downregulated. Thus, it has been reported that SMG1 may contribute in identifying the prognosis of HCC.

特徴および利点

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

関連事項

Corresponding Antigen APREST71035

物理的形状

PBS溶液 (pH 7.2, 40%グリセロ-ル, 0.02%アジ化ナトリウム含有)

法的情報

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)