由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
分子量
antigen ~34 kDa
化学種の反応性
human
濃度
~1.0 mg/mL
テクニック
immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human HOXC8
western blot: 1-2 μg/mL using extracts of HEK-293T cells over expressing human HOXC8
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... HOXC8(3224)
mouse ... Hoxc8(15426)
rat ... Hoxc8(24460)
詳細
Homeobox C8 (HOXC8) is a member of homeobox (HOX) family. It is a transcription factor, expressed in neural tube, brain, breast and adult bone marrow. HOX genes consist of a highly conserved 60-amino-acid region (the homeobox) with DNA-binding activity, that contributes to their activity as transcription factors. The gene is located on human chromosome 12q13.
免疫原
synthetic peptide corresponding to amino acids 96-110 of human HOXC8 conjugated to KLH. The corresponding sequence is identical in mouse and rat.
アプリケーション
Anti-HOXC8 antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.
生物化学的/生理学的作用
Homeobox C8 (HOXC8) is involved in cell growth, migration and metastasis of various cancers. Hox genes are important for embryonic development. Mutations in this gene are implicated in the development of cancers, such as leukemias or neoplasms of the breast, prostate, kidney, colon, skin and brain.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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試験成績書(COA)
製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Molecular cancer, 16(1), 38-38 (2017-02-17)
Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain homeostasis of normal tissues. Here, we screened the expression of homeobox
Journal of assisted reproduction and genetics, 37(10), 2535-2544 (2020-08-11)
To evaluate whether miR-148a-3p overexpression is associated with disrupted decidualization of recurrent implantation failure (RIF). Endometrial miRNA and mRNA expression profiles during the implantation window derived from women with and without RIF were identified using microarray and RT-qPCR. Immortalized human
Embigin, regulated by HOXC8, plays a suppressive role in breast tumorigenesis
Oncotarget, 6(27), 23496-23496 (2015)
Overexpression of HOXC8 is associated with poor prognosis in epithelial ovarian cancer
Reproductive Sciences, 23(7), 944-954 (2016)
The predictive potential and oncogenic effects of HOXC8 expression on osteosarcoma
Tumor Biology, 37(11), 14961-14967 (2016)
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