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Merck

H1666

Sigma-Aldrich

抗HOXC4(N末端)抗体 ウサギ宿主抗体

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

別名:

抗Hox-3E CP19抗体, 抗ホメオボックス3E抗体, 抗ホメオボックスC4抗体

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About This Item

UNSPSCコード:
12352203
NACRES:
NA.41

由来生物

rabbit

結合体

unconjugated

抗体製品の状態

affinity isolated antibody

抗体製品タイプ

primary antibodies

クローン

polyclonal

フォーム

buffered aqueous solution

分子量

antigen ~40 kDa

交差性

human

濃度

~1.0 mg/mL

テクニック

immunoprecipitation (IP): 2.5-5 μg/mL using lysates of HEK-293T cells over-expressing human HOXC4
indirect immunofluorescence: 1-2 μg/mL using paraformaldehyde-fixed HEK-293T cells over-expressing human HOXC4
western blot: 0.5-1 μg/mL using lysates of HEK-293T cells over-expressing human HOXC4

UniProtアクセッション番号

輸送温度

dry ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... HOXC4(3221)
mouse ... Hoxc4(15423)
rat ... Hoxc4(24459)

詳細

The Homeobox C4 (HOXC4) is located on the human chromosome at 12q13.13.

特異性

Anti-HOXC4 (N-terminal) recognizes human HOXC4 (also known as Hox-3E and CP19).

アプリケーション

Anti-HOXC4 (N-terminal) antibody produced in rabbit may be used in:
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

生物化学的/生理学的作用

Homeobox C4 (HOXC4) transcription factor/protein stimulates the action of activation-induced cytosine deaminase (AID). The HOXC4 gene is upregulated due to the estrogen-estrogen receptor complexes. HOXC4 gene is expressed in the proliferating lymphocytes of B-, T- and natural killer (NK) cell lineage. This gene expression is elevated with the progression of lymphoid differentiation.

物理的形状

0.01 M PBS溶液(pH 7.4, 15 mMアジ化ナトリウム含有)。

保管および安定性

Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

引火点(°F)

Not applicable

引火点(℃)

Not applicable


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

H1666-200UL:
H1666-25UL:
H1666-VAR:
H1666-BULK:


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文書ライブラリにアクセスする

R Meazza et al.
Blood, 85(8), 2084-2090 (1995-04-15)
We have analyzed the expression of homeoproteins of the HOX family in resting and activated lymphoid cells and in neoplastic lymphoid cell lines by the use of monoclonal antibodies (MoAbs) already shown to react with the homeoproteins HOXA10, HOXC6, and
J van Oostveen et al.
Leukemia, 13(11), 1675-1690 (1999-11-11)
In the last decade it has become clear that homeobox containing genes (HOX genes) not only play a significant role in regulating body formation, but in addition, they are contributing to organization and regulation of hematopoiesis. Modern molecular technologies showed
Seok-Rae Park et al.
Cytokine, 61(2), 608-613 (2012-11-28)
Activation-induced cytidine deaminase (AID) plays a key role in B cell immunoglobulin (Ig) class switch recombination (CSR) and somatic hypermutation (SHM). We have previously reported that the highly conserved homeodomain HoxC4 transcription factor binds to the Aicda (AID gene) promoter
Frank Mendrzyk et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 12(7 Pt 1), 2070-2079 (2006-04-13)
Pathogenesis of ependymomas is still poorly understood and molecular markers for risk-adapted patient stratification are not available. Our aim was to screen for novel genomic imbalances and prognostic markers in ependymal tumors. We analyzed 68 sporadic tumors by matrix-based comparative
Thach Mai et al.
The Journal of biological chemistry, 285(48), 37797-37810 (2010-09-22)
Estrogen enhances antibody and autoantibody responses through yet to be defined mechanisms. It has been suggested that estrogen up-regulates the expression of activation-induced cytosine deaminase (AID), which is critical for antibody class switch DNA recombination (CSR) and somatic hypermutation (SHM)

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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