由来生物
chicken
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
交差性
human, mouse
メーカー／製品名
Genway 15-288-22849
テクニック
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... SLC12A2(6558)
免疫原
Immunogen Sequence: GI # 4506975, sequence 114-285
Recombinant solute carrier family 12 (sodium/potassium/chloride transporters), member 2
アプリケーション
Anti-SLC12A2 (ab2) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生物化学的／生理学的作用
The Na-K-Cl cotransporter (NKCC) is a protein that helps in the active transport of sodium, potassium, and chloride into and out of cells. It couples the movement of Na+, K+ and Cl- ions across the plasma membrane of most animal cells and plays a central role in cellular homeostasis and human physiology. The proteins play important roles in Na+ and K+ concentrations in key physiological systems, including cardiac, vascular, renal, nervous and sensory systems. NKCC1 levels and functionality are altered in certain disease states. NKCC1 may play a role in glioma cell migration, the precise mechanism by which ion transporter contributes to Glioblastoma (GB) aggressiveness. Its expression levels are found to be significantly higher in GB and anaplastic astrocytoma tissues than in grade II glioma and normal cortex. It also plays a central role in cellular chloride homeostasis and in epithelial salt transport.
物理的形状
Solution in phosphate buffered saline containing 0.02% sodium azide.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
GW22849-50UG:
GW22849-VAR:
GW22849-BULK:
最新バージョンのいずれかを選択してください：
Suma Somasekharan et al.
PloS one, 8(12), e82060-e82060 (2013-12-18)
The Na-K-Cl cotransporter (NKCC) couples the movement of Na(+), K(+), and Cl(-) ions across the plasma membrane of most animal cells and thus plays a central role in cellular homeostasis and human physiology. In order to study the structure, function
Suma Somasekharan et al.
The Journal of biological chemistry, 287(21), 17308-17317 (2012-03-23)
The Na-K-Cl cotransporter (NKCC) plays central roles in cellular chloride homeostasis and in epithelial salt transport, but to date little is known about the mechanism by which the transporter moves ions across the membrane. We examined the functional role of
Tomas Garzon-Muvdi et al.
PLoS biology, 10(5), e1001320-e1001320 (2012-05-10)
Glioblastoma (GB) is a highly invasive and lethal brain tumor due to its universal recurrence. Although it has been suggested that the electroneutral Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1) can play a role in glioma cell migration, the precise mechanism by which
Bo Ding et al.
American journal of physiology. Cell physiology, 306(1), C66-C75 (2013-11-01)
Sodium/potassium/chloride cotransporter (NKCC1) proteins play important roles in Na(+) and K(+) concentrations in key physiological systems, including cardiac, vascular, renal, nervous, and sensory systems. NKCC1 levels and functionality are altered in certain disease states, and tend to decline with age.
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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