由来生物
chicken
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
交差性
human
メーカー／製品名
Genway 15-288-21069
テクニック
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... CCL7(6354)
アプリケーション
Anti-CCL7 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生物化学的／生理学的作用
Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine, earlier called as monocyte-specific chemokine 3 (MCP3). It regulates macrophage functions. It belongs to the monocyte chemotactic protein (MCP) subfamily of the CC chemokines and is produced by astrocytes. The CCL7 gene is mapped to chromosome 17 on subbands q11.2-q12. It induces production of gelatinase B and chemotaxis of monocytes. It is often produced by tumor cell lines and regulates protease secretion by macrophages. CCL7 production may contribute to invasion and metastasis of cancer cells. It may act as a novel target metastasis of colorectal cancer (CRC) and may be of potential clinical value for the prevention of hepatic recurrences. CCL7 may have a role in vascular pathology as well.
物理的形状
Solution in phosphate buffered saline containing 0.02% sodium azide.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
GW21069-50UG:
GW21069-VAR:
GW21069-BULK:
最新バージョンのいずれかを選択してください：
Nicole A Renner et al.
Journal of neurovirology, 17(2), 146-152 (2011-02-01)
Monocyte/macrophages and activated lymphocytes traffic through normal brain, and this trafficking is increased in inflammatory conditions such as HIV encephalitis (HIVE). HIVE is characterized in part by perivascular accumulations of macrophages. The earliest events in this process are poorly understood
Yong Beom Cho et al.
Oncology reports, 28(2), 689-694 (2012-05-23)
The main cause of death for colorectal cancer (CRC) patients is the development of metastatic lesions at sites distant from the primary tumor. Therefore, it is important to find biomarkers that are related to the metastasis and to study the
Marcella Maddaluno et al.
Atherosclerosis, 217(1), 113-119 (2011-05-04)
Monocyte chemotactic protein-3 (MCP-3), also known as CCL7, belongs to the monocyte chemotactic protein (MCP) subfamily of the CC chemokines that includes MCP-1/CCL2, MCP-2/CCL8, MCP-4/CCL13, and MCP-5/CCL12. Few studies have examined the role of MCP-3 in vascular pathologies such as
G Opdenakker et al.
Genomics, 21(2), 403-408 (1994-05-15)
Monocyte chemotactic proteins (MCPs) are chemokines involved in macrophage recruitment during inflammation and cancer. A full-size MCP-3 cDNA was used to isolate the functional human MCP-3 gene. Based on restriction analysis, subclones were selected and the MCP-3 gene sequence was
G Opdenakker et al.
Biochemical and biophysical research communications, 191(2), 535-542 (1993-03-15)
When human MG-63 osteosarcoma cells are triggered with IL-1 beta, they produce, among various other cytokines, also monocyte chemotactic proteins (MCPs). Homogeneous MCP-1, MCP-2 and MCP-3 were found to induce production of gelatinase B and chemotaxis of monocytes. Based on
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