F9679

抗脂肪酸シンターゼ (C-末端) ウサギ宿主抗体

1 mg/mL, affinity isolated antibody, buffered aqueous solution

• 別名: 抗FASN抗体, 抗FAS抗体
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD00283209
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: 9

特性

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 270 kDa
• species reactivity: mouse, rat, human
• concentration: 1 mg/mL
• technique(s): western blot: 0.5-1 μg/mL using lysates of Rat1 cells, western blot: 1-2 μg/mL using lysates of human HEK 293-T cells
• UniProt accession no.: P49327
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... FASN(2194) ; mouse ... Fasn(14104) ; rat ... Fasn(50671)

詳細

General description

Fatty acid synthase (FAS, FASN) is a multifunctional protein, mainly involved in catalyzing the synthesis of palmitate from acetyl-CoA and malonyl CoA, in the presence of NADPH. In mammals, it is composed of two identical multifunctional polypeptides, in which three catalytic domains in the N-terminal section (β-ketoacyl synthase, malonyl/acetyl tansferase, and dehydrase) are separated by a core region of about 600 residues from four C-terminal domains (enoyl reductase, β-ketoacyl reductase, acyl carrier protein, and thioesterase).

Immunogen

ヒト脂肪酸シンタ-ゼのアミノ酸2497-2511に相当する合成ペプチド(N末端リジン付加)のKLH結合体。相当する配列はヒト、ラット、マウスで保存されています。

Application

Anti-Fatty Acid Synthase (C-Terminal) antibody is suitable for western blot analysis at a concentration of 0.5-1μg/mL using lysates of Rat1 cells and 1-2μg/mL using lysates of human HEK 293-T cells.

Biochem/physiol Actions

FAS plays an essential role during embryogenesis and energy homeostasis in adult animals. It also acts as the carbon source for fatty acid synthesis. It has been shown to be overexpressed in various types of human cancer, including prostate, breast, ovary and others.

Physical form

0.01M PBS溶液 (pH 7.4, 15mMアジ化ナトリウム含有)。

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)