由来生物
human
リコンビナント
expressed in baculovirus infected Sf21 cells
アッセイ
>90% (SDS-PAGE)
フォーム
lyophilized powder
有効性
1-3 ng/mL ED50
分子量
monomer calculated mol wt 66 kDa
~100 kDa by SDS-PAGE (reducing)
保管条件
avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
不純物
<1 EU/μg Endotoxin level (LAL test)
UniProtアクセッション番号
保管温度
−20°C
遺伝子情報
human ... FGFR2(2263)
詳細
FGFR2 (fibroblast growth factor receptor 2) is a member of the tyrosine kinase receptor family called FGFR. This gene is localized to human chromosome 10q26, and is composed of 2 exons.
Its ligand-binding domain in present in its extracellular region, which is composed of three immunoglobulin (Ig)-like domains. It spans the membrane once, and its tyrosine kinase domain is localized to its intracellular region. Alternative splicing of this gene gives rise to two isoforms- epithelial (FGFR2IIIb) and mesenchymal (FGFR2IIIc).
Its ligand-binding domain in present in its extracellular region, which is composed of three immunoglobulin (Ig)-like domains. It spans the membrane once, and its tyrosine kinase domain is localized to its intracellular region. Alternative splicing of this gene gives rise to two isoforms- epithelial (FGFR2IIIb) and mesenchymal (FGFR2IIIc).
生物化学的／生理学的作用
FGFR2 (fibroblast growth factor receptor 2) facilitates tumor growth, invasiveness, metastasis and angiogenesis. It plays an essential role in the development of mammary glands, and its expression is elevated in breast cancers. Studies in North Indian population suggest that polymorphisms in this gene might be linked to susceptibility to breast cancer. It is anti-apoptotic in nature, and suppresses p53-mediated apoptosis, by inducing the elevation of MDM2 levels. Mutations in this gene are linked to mild Crouzon syndrome and craniosynostosis.
物理的形状
凍結乾燥品(0.2μmフィルタ-滅菌済みPBS)。
アナリシスノート
生物活性は、ヒト酸性線維芽細胞増殖因子によるNR6細胞の増殖に対する阻害能で測定しています。
その他情報
リコンビナントヒトFGFR-2α(IIIb)/Fcは、ジスルフィド結合によるホモ二量体タンパク質です。糖鎖修飾の結果、電気泳動でこのタンパク質は約100 kDaの位置に移動します。
最新バージョンのいずれかを選択してください：
Zahra Saadatian et al.
Asian Pacific journal of cancer prevention : APJCP, 15(18), 7955-7958 (2014-10-09)
Breast cancer is the most common cancer among women in the world. In Iran, the incidence of breast cancer is on the increase. We here studied the association of rs1219648 in FGFR2 and rs1042522 in TP53 and their interaction in
Aimee L Fenwick et al.
BMC medical genetics, 15, 95-95 (2014-09-02)
Mutations of fibroblast growth factor receptor 2 (FGFR2) account for a higher proportion of genetic cases of craniosynostosis than any other gene, and are associated with a wide spectrum of severity of clinical problems. Many of these mutations are highly
Sarah Siddiqui et al.
PloS one, 9(10), e110426-e110426 (2014-10-22)
Genome-Wide Association Studies (GWAS) have identified Fibroblast growth factor receptor 2 (FGFR2) as a candidate gene for breast cancer with single nucleotide polymorphisms (SNPs) located in intron 2 region as the susceptibility loci strongly associated with the risk. However, replicate
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