由来生物
mouse
結合体
FITC conjugate
phycoerythrin (R-PE) conjugate
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
BRA-55/UCHM-1, monoclonal
フォーム
buffered aqueous solution
交差性
human
テクニック
flow cytometry: 20 μL using 1 × 106 cells
アイソタイプ
IgG1/IgG2a
UniProtアクセッション番号
輸送温度
wet ice
保管温度
2-8°C
遺伝子情報
human ... CD14(929) , PTPRC(5788)
アプリケーション
Monoclonal Anti-CD45-FITC/CD14-PE DUAL-TAG™ antibody is suitable for flow cytometry at a concentration of 20μL using 1×106 cells.
生物化学的／生理学的作用
CD45 is a family of single chain transmembrane glycoproteins, consisting of different isoforms, which share a common large intracellular domain. It is abundantly present in leukocyte cell surface and belongs to a novel class of enzymes, the protein tyrosine phosphatases (PTPs). It plays an essential role in thymic selection and peripheral activation of T and B cells. It is associated with various signal transduction pathways. It may also accelerate the Src family tyrosine kinases activity. an important determinant of immune tolerance.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
法的情報
DUAL-TAG is a trademark of Sigma-Aldrich Co. LLC
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
適切な製品が見つかりませんか。
製品選択ツール.をお試しください
最新バージョンのいずれかを選択してください：
Calvin C K Yu et al.
Current directions in autoimmunity, 6, 61-88 (2002-11-01)
Mutations in a number of signaling components in mice can lead to strong autoimmune phenotypes. In some cases, these mutations likely compromise important feedback inhibitory pathways that downregulate antigen receptor signaling. For example, a deficiency of Lyn leads to a
I S Trowbridge et al.
Annual review of immunology, 12, 85-116 (1994-01-01)
CD45 is one of the most abundant leukocyte cell surface glycoproteins and is expressed exclusively upon cells of the hematopoietic system. Different isoforms of CD45 are generated by alternative splicing and are expressed in cell type-specific patterns on functional subpopulations
B Tackenberg et al.
Autoimmunity, 36(2), 117-121 (2003-06-25)
In myasthenia gravis (MG), humoral and cellular immune mechanisms are involved in the autoimmune pathogenesis. In this study, we investigated the role of the CD45 molecule in MG, having recently reported an association in multiple sclerosis. CD45, a protein-tyrosine phophatase
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）