由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen ~30 kDa by calculation
交差性
human
テクニック
western blot: 1:500-1:1,000
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
遺伝子情報
human ... FBXO44(93611)
mouse ... Fbxo44(230903)
rat ... Fbxo44(500587)
免疫原
peptide corresponding to the human FBG3 protein (amino acids 103-119). This sequence has 94% homology with mouse and rat.
アプリケーション
Anti-FBG3 (FBXO44) antibody is suitable for western blot: 1:500-1:1,000.
生物化学的／生理学的作用
F-box protein, is the critical component of conserved ubiquitin–protein ligase complex SCF (Skp1/Cdc53-Cullin1/F-box) and acts as a substrate recognition component of the ubiquitin ligase complex SCF (Skp-Cullin-F-box). It is expressed in human tissues including kidney, liver, brain and muscle tissues. It is associated with various critical biological processes such as in regulating the cell cycle, immune response, signaling cascades and developmental programs. The proteins have a bipartite structure and the core complex, whereas divergent protein-protein interaction motifs selectively bind their cognate substrates.
物理的形状
Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
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保管分類コード
10 - Combustible liquids
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください：
Gennady P Ilyin et al.
Gene, 296(1-2), 11-20 (2002-10-18)
F-box proteins, a critical component of the evolutionary conserved ubiquitin-protein ligase complex SCF (Skp1/Cdc53-Cullin1/F-box), recruit substrates for ubiquitination and consequent degradation through their specific protein-protein interaction domains. Here, we report the identification of full-length cDNAs encoding three novel human F-box
K L Craig et al.
Progress in biophysics and molecular biology, 72(3), 299-328 (1999-12-03)
The ubiquitin system of intracellular protein degradation controls the abundance of many critical regulatory proteins. Specificity in the ubiquitin system is determined largely at the level of substrate recognition, a step that is mediated by E3 ubiquitin ligases. Analysis of
Laura Pontano Vaites et al.
Molecular and cellular biology, 31(22), 4513-4523 (2011-09-14)
Skp1-Cul1-F-box (SCF) E3 ubiquitin ligase complexes modulate the accumulation of key cell cycle regulatory proteins. Following the G(1)/S transition, SCF(Fbx4) targets cyclin D1 for proteasomal degradation, a critical event necessary for DNA replication fidelity. Deregulated cyclin D1 drives tumorigenesis, and
Margaret S Ho et al.
Journal of biomedical science, 13(2), 181-191 (2006-02-08)
The eukaryotic protein degradation pathway involves the ubiquitin (Ub) modification of substrates targeted for degradation by the 26S proteasome. The addition of Ub, a process called ubiquitination, is mediated by enzymes including the E3 Ub ligases which transfer the Ub
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