由来生物
sheep
結合体
unconjugated
抗体製品の状態
fractionated antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
分子量
antigen 52 kDa
化学種の反応性
human, mouse
テクニック
western blot: suitable using whole extracts from mouse erythroleukemia cell lines, DP16-1 and CB7 and human T-cell line.
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
遺伝子情報
human ... FLI1(2313)
mouse ... Fli1(14247)
免疫原
GST fusion protein of the N-terminus of Fli-1 corresponding to amino acids 1-239.
アプリケーション
Anti-FLI-1 antibody produced in sheep is suitable for western blotting using whole extracts from mouse erythroleukemia cell lines, DP16-1 and CB7 and human T-cell line.
生物化学的／生理学的作用
Friend leukemia integration 1 transcription factor (FLI1) is a protein that is encoded by the FLI1 gene in humans and is a member of Ets transcription factor family. It is a proto-oncogene and located on human chromosome 11q23-24. FLI1 may be involved in human sarcomas, leukemias and lymphomas. It may play an important role in the posttranscriptional regulation of the Fli-1 transcript. Alteration in the transcriptional activation function of Fli-1 may be responsible for human malignancies. It is a novel ETS transcription factor involved in gene fusions in prostate cancer.
物理的形状
Solution in 0.01 M phosphate buffered saline, containing 0.08% sodium azide
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
V N Rao et al.
Oncogene, 8(8), 2167-2173 (1993-08-01)
Three of the ets oncogene superfamily members v-ets, Spi-1/PU.1 and Fli-1, have been shown to be directly involved in retroviral-mediated acute erythroleukemias. The Fli-1 gene was found to be rearranged in 75% of the erythroleukemias induced by Friend murine leukemia
Steven M Kornblau et al.
Blood, 118(20), 5604-5612 (2011-09-16)
Friend leukemia virus integration 1 (FLI1), an Ets transcription factor family member, is linked to acute myelogenous leukemia (AML) by chromosomal events at the FLI1 locus, but the biologic impact of FLI1 expression on AML is unknown. FLI1 protein expression
Paula Paulo et al.
Genes, chromosomes & cancer, 51(3), 240-249 (2011-11-15)
To characterize the pattern of ETS rearrangements and to uncover novel ETS fusion genes, we analyzed 200 prostate carcinomas (PCa) with TaqMan low-density arrays (TLDAs), followed by selective analyses with fluorescence in situ hybridization (FISH), RT-PCR, and sequencing. Besides confirming
D D Prasad et al.
Cancer research, 52(20), 5833-5837 (1992-10-15)
Three ets family members, v-ets, spleen focus forming virus proviral integration 1/Pu.1, and Friend leukemia integration 1 (Fli-1), were shown to be involved in retroviral mediated acute leukemias suggesting that ets family members play a crucial role in transformation. Mouse
V Baud et al.
Genomics, 11(1), 223-224 (1991-09-01)
FLI1 is a common mouse viral integration region in virus-induced leukemias and lymphomas. Using an evolutionarily conserved mouse probe and Southern hybridization to (rodent x human) somatic cell hybrid DNAs, the human homolog of FLI1 has been shown to lie
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