D9696

ドロネダロン 塩酸塩

≥98% (HPLC)

• 別名: Multaq, SR-33589B
• 実験式（ヒル表記法）: C₃₁H₄₄N₂O₅S · HCl
• CAS番号: 141625-93-6
• 分子量: 593.22
• NACRES: NA.77
• PubChem Substance ID: 329798909
• UNSPSC Code: 12352200
• MDL number: MFCD00914940
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

特性

• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: 15 mg/mL, clear
• originator: Sanofi Aventis
• storage temp.: 2-8°C
• SMILES string: Cl.CCCCN(CCCC)CCCOc1ccc(cc1)C(=O)c2c(CCCC)oc3ccc(NS(C)(=O)=O)cc23
• InChI: 1S/C31H44N2O5S.ClH/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3;/h13-18,23,32H,5-12,19-22H2,1-4H3;1H
• InChI key: DWKVCQXJYURSIQ-UHFFFAOYSA-N
• Gene Information: human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), HCN4(10021), KCNJ2(3759), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

詳細

Application

Dronedarone hydrochloride has been used as an anti-arrhythmic drug to assess its impact in P19C5 embryoid bodies (EBs). It has also been used to determine its antiviral potency.

Biochem/physiol Actions

Dronedarone is a synthetic derivative of amiodarone, which belongs to the class of benzofurane anti-arrhythmic compounds. It might moderately block cytochrome P450 3A4 (CYP3A4) activity. Dronedarone is used to treat atrial flutter.

ドロネダロンは、クラスIIIの抗不整脈薬であり、心房細動のためのマルチチャネル遮断薬です。

ドロネダロンは、クラスIIIの抗不整脈薬であり、心房細動のためのマルチチャネル遮断薬です。カリウム、ナトリウム、カルシウムチャネルを遮断し、また、抗アドレナリン特性も示します。

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• 保管分類: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable