アッセイ
>98% (HPLC)
フォーム
solid
色
light yellow
溶解性
DMSO: soluble 22 mg/mL
H2O: insoluble
輸送温度
wet ice
保管温度
−20°C
SMILES記法
CN(N=O)c1cc(O)ccc1O
遺伝子情報
human ... PTPRCAP(5790)
生物化学的／生理学的作用
プロテインチロシンホスファタ-ゼCD45のインヒビタ-です。
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
D8065-VAR:
D8065-5MG:
D8065-BULK:
D8065-1MG:
最新バージョンのいずれかを選択してください：
A Hiroki et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 56(4), 179-185 (2002-07-12)
Et-3,4-dephostatin, a protein-tyrosine phosphatase (PTPase) inhibitor, potentiates insulin-dependent signal transduction and shows an antidiabetic effect in mice. However, it contains a nitrosamine moiety that is often mutagenic and carcinogenic. Therefore, we previously designed and synthesized methoxime-3,4-dephostatin as a nitrosamine-free analogue
Gang Liu
Current medicinal chemistry, 10(15), 1407-1421 (2003-07-23)
Protein tyrosine phosphatase 1B (PTP1B) has been implicated as one of the key negative regulators of insulin and leptin signal transduction pathways. PTP1B deficient mice are more sensitive to insulin, and have improved glycemic control and resistance to diet-induced obesity
S M Thoroed et al.
Pflugers Archiv : European journal of physiology, 438(2), 133-140 (1999-06-17)
The effects of the protein tyrosine phosphatase (PTP) inhibitors, pervanadate, monoperoxo(picolinato)- oxo-vanadate(V) [mpV(pic)] and dephostatin, on regulatory volume decrease (RVD) and the volume-sensitive Cl- current in mouse L-fibroblasts were studied with the aid of video microscopy and the whole-cell patch-clamp
S Wakino et al.
The Journal of biological chemistry, 276(50), 47650-47657 (2001-10-13)
The cyclin-dependent kinase inhibitor p21(Cip1) is up-regulated in response to mitogenic stimulation in various cells. PPARgamma ligands troglitazone (TRO, 10 microm) and rosiglitazone (RSG, 10 microm) attenuated the induction of p21(Cip1) protein by platelet-derived growth factor (PDGF) and insulin without
K Umezawa
Advances in enzyme regulation, 37, 393-401 (1997-01-01)
We have isolated signal transduction inhibitors of low molecular weight from microorganisms and plants. Since inducers of differentiation and apoptosis may be developed as new anticancer agents, we have studied induction of differentiation and apoptosis in neoplastic cells by our
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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