D4813
デンドロトキシン-K
≥98% (HPLC), potassium channels inhibitor, lyophilized powder
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| あなたへ/カタログ番号 | 在庫状況 | 単価 |
|---|---|---|
1 vial | カートの在庫状況を確認する | ￥57,300 |
この商品について
Assay:
≥98% (HPLC)
Form:
lyophilized powder
製品名
デンドロトキシン-K, ≥98% (HPLC), lyophilized powder
Quality Segment
assay
≥98% (HPLC)
form
lyophilized powder
mol wt
6,542 Da
storage temp.
−20°C
Application
Dendrotoxin-K is suitable for use as a potassium voltage-gated channel subfamily A member 1 (Kv1.1) channel blocker in axon and human embryonic kidney (HEK293) cells.[1] It has also been used as a selective blocker of Kv channels in mice.
Biochem/physiol Actions
Dendrotoxin-K (DTXk) is isolated from mamba snake Dendroaspis polylepis and interacts with the β-turn region in the N-terminal sequence of the potassium channel. It inhibits tumor progression in gefitinib-resistant non-small cell lung cancer cells. DTXk induces neuronal damage in the hippocampus via N-methyl-d-aspartate (NMDA) and non-NMDA receptors.
デンドロトキシン-KはKv1.1タンパク質を含むカリウムチャネルのみ阻害します。[2]
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Other Notes
もとはDendroaspis polylepis polylepis (ブラックマンバ)の毒液から単離されました。
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当該品目 | |||
|---|---|---|---|
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form powder |
| assay ≥98% (HPLC) | assay >98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| mol wt 6,542 Da | mol wt 3921 Da | mol wt - | mol wt - |
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)