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Merck

D2022

Sigma-Aldrich

5,6-Dihydrothymidine

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About This Item

実験式(ヒル表記法):
C10H16N2O5
CAS番号:
分子量:
244.24
MDL番号:
UNSPSCコード:
12352204

保管温度

−20°C

SMILES記法

CC1CN(C2CC(O)C(CO)O2)C(=O)NC1=O

保管分類コード

13 - Non Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Gloves, type N95 (US)


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K A Tallman et al.
Journal of the American Chemical Society, 123(22), 5181-5187 (2001-07-18)
5,6-Dihydrothymidin-5-yl (1) was independently generated in a dinucleotide from a phenyl selenide precursor (4). Under free radical chain propagation conditions, the products resulting from hydrogen atom donation and radical-pair reaction are the major observed products in the absence of O(2).
M Weinfeld et al.
Nucleic acids research, 21(3), 621-626 (1993-02-11)
Stacking between aromatic amino acids and nucleic acid bases may play an important role in the interaction of enzymes with nucleic acid substrates. In such circumstances, disruption of base aromaticity would be expected to decrease enzyme activity on the modified
J Cadet et al.
International journal of radiation biology and related studies in physics, chemistry, and medicine, 39(2), 119-133 (1981-02-01)
The steady-state gamma radiolysis of deaerated aqueous solutions of thymidine generated a complex mixture of pyrimidine and nucleoside derivatives. Twenty-two of these compounds have been isolated and unambiguously characterized by spectroscopic methods including proton nuclear magnetic resonance and mass spectrometry.
E A Furlong et al.
Biochemistry, 25(15), 4344-4349 (1986-07-29)
5,6-Dihydrothymidine (dDHT) is a derivative thymidine formed during gamma-irradiation. This paper demonstrates the conditions under which dDHT is formed in solutions of DNA and that dDHT is produced in the DNA of HeLa cells during gamma-irradiation. The product of dDHT
Marie-Hélène David-Cordonnier et al.
Biochemistry, 41(2), 634-642 (2002-01-10)
A major DNA lesion induced by ionizing radiation and formed on removal of oxidized base lesions by various glycosylases is an apurinic/apyrimidinic site (AP site). The presence of an AP site within clustered DNA damage, induced following exposure to ionizing

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