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About This Item
実験式（ヒル表記法）:
C8H9Cl2N · HCl
CAS番号:
分子量:
226.53
MDL番号:
UNSPSCコード:
12352202
PubChem Substance ID:
形状
solid
色
white
溶解性
H2O: soluble (Solutions may be stored for 1-2 days at 4 °C.)
ethanol: soluble (Solutions may be stored for 1-2 days at 4 °C.)
SMILES記法
Cl[H].CC(N)c1cccc(Cl)c1Cl
遺伝子情報
human ... PNMT(5409)
生物化学的／生理学的作用
PNMT inhibitor.
保管分類コード
13 - Non Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
T A Glauser et al.
Xenobiotica; the fate of foreign compounds in biological systems, 23(6), 657-669 (1993-06-01)
1. Thiol methyltransferase (TMT) is a microsomal enzyme catalyzing the S-methylation of aliphatic sulphydryl drugs and xenobiotics. Studies of the functional significance of S-methylation catalysed by TMT have been hampered by lack of a potent, relatively specific, non-toxic inhibitor of
S P Kalra et al.
Endocrinology, 111(4), 1403-1405 (1982-10-01)
Administration of the opiate receptor antagonist, naloxone, evoked rapid rises in plasma LH levels in estrogen, progesterone-primed ovariectomized rats. Pretreatment with a peripherally acting epinephrine (EPI) synthesis inhibitor, SK&F 29661, failed to influence the naloxone-induced LH release. However, two centrally
R W Fuller
Annual review of pharmacology and toxicology, 22, 31-55 (1982-01-01)
Neurons that contain PNMT, the epinephrine-forming enzyme, have their cell bodies in brain stem regions in rat brain and send projections mainly into other brain stem areas, hypothalamus, and spinal cord. These neurons can be affected pharmacologically by various kinds
N Y Liang et al.
The Journal of pharmacology and experimental therapeutics, 223(2), 382-387 (1982-11-01)
Intraperitoneal injections of the phenylethanolamine N-methyltransferase inhibitors 2-cyclohexyl-2-hydroxyethylamine, 1-aminomethylcycloundecanol, 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline and 2,3-dichloro-alpha-methylbenzylamine all lowered blood pressures in spontaneously hypertensive rats. The drugs did not affect the blood pressures of age-paired normotensive Wistar Kyoto rats or did the drugs alter the
G Engberg et al.
Brain research, 223(1), 49-58 (1981-10-26)
The functional significance of the morphologically identified adrenaline (A)-mediated input to the noradrenergic nucleus locus coeruleus (LC) was pharmacologically analyzed. By means of single unit recording techniques the LC neurons in the rat brain were studied following administration of SK&F
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