C8990

Sp-8-pCPT-cAMPS

≥98% (HPLC), solid

• 別名: 8-(4-クロロフェニルチオ)アデノシン-3',5'-環状モノホスホロチオアート, Sp-アイソマー ナトリウム塩
• 実験式（ヒル表記法）: C₁₆H₁₄ClN₅O₅PS₂Na
• CAS番号: 129693-13-6
• 分子量: 509.86
• MDL番号: MFCD04113743
• UNSPSCコード: 12352200
• PubChem Substance ID: 24724452

特性

• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 包装: vial of 5 μmol
• 溶解性: H₂O: >1 mg/mL
• 輸送温度: dry ice
• 保管温度: −70°C
• SMILES記法: [Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([S-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12

詳細

詳細

Sp-8-pCPT-cAMPS is a nonhydrolyzable analog of cAMP with a p-chlorophenylthio moiety.

アプリケーション

Sp-8-pCPT-cAMPS has been used as an agonist for protein kinase A. It has also been used in the inhibition of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) in oligosphere cultures.

生物化学的／生理学的作用

Selective cAMP-dependent protein kinase (PKA) activator.

Sp-8-pCPT-cAMPS impairs PIP2 production by phosphatidylinositol 4-phosphate 5-kinase (PIP5K) inhibition. It may be involved in promoting remyelination in astrocytes and neurons. The lipophilicity feature of Sp-8-pCPT-cAMPS aids its cell entry for mediating remyelination. It may play a role in lowering Leishmania proliferation in in vitro studies.

安全性情報

• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)