おすすめの製品
アッセイ
≥98% (HPLC)
フォーム
powder
色
white to off-white
溶解性
DMSO: >10 mg/mL
保管温度
2-8°C
SMILES記法
FC(F)(F)c1c(ccc(c1)NC(=O)c2c(cccc2)OCC)Cl
InChI Key
YDXZSNHARVUYNM-UHFFFAOYSA-N
詳細
CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is derived from anacardic acid.[1]
アプリケーション
CTB has been used to study its apoptotic effects on P53 protein acetylation.[2]
生物化学的／生理学的作用
CTPBは、ヒストンアセチルトランスフェラーゼp300のアクチベーターとして初めて知られた低分子化合物です。CTBは、CTPBと同程度かあるいはそれ以上の活性を発揮するCTPBの単純化アナログです。この化合物は、p300/EP300/E1A結合タンパク質のHAT活性を賦活化します。現在、その他HATアクチベーターは取り扱っておりません。
ヒストンアセチルトランスフェラーゼ(HAT)p300/CBP(CREB結合タンパク質)のアクチベーターです。
Small molecule activators of HAT such as CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is useful for altering chromatin acetylation directly. It might serve as a therapeutic agent for treating the complications of cognitive dysfunction including neuropsychiatric, neurodevelopmental and neurodegenerative diseases.[1]
特徴および利点
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
保管分類コード
11 - Combustible Solids
WGK
WGK 2
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
C6499-25MG:
C6499-VAR:
C6499-BULK:
C6499-5MG:
最新バージョンのいずれかを選択してください：
試験成績書（COA）
Lot/Batch Number
Willian S Korim et al.
Cardiovascular research, 115(6), 1092-1101 (2018-10-26)
Neuroinflammation is a common feature in renovascular, obesity-related, and angiotensin II mediated hypertension. There is evidence that increased release of the pro-inflammatory cytokine tumour necrosis factor-α (TNF-α) contributes to the development of the hypertension, but the underlying neural mechanisms are
The effect of CTB on P53 protein acetylation and consequence apoptosis on MCF-7 and MRC-5 cell lines
Dastjerdi MN, et al.
Advanced Biomedical Research, 2 (2013)
DeMetris D Reed et al.
Meat science, 123, 205-210 (2016-10-19)
Palatability attributes of beef striploin steaks mechanically enhanced with pork fat were evaluated. Striploins were collected from USDA Standard steer carcasses, longitudinally cut into halves (lateral or medial) and assigned randomly to pork fat injection (PFI) or non-injected control (CON).
Franklin D Echevarria et al.
Frontiers in neuroscience, 11, 318-318 (2017-06-18)
The pleotropic cytokine interleukin-6 (IL-6) is implicated in retinal ganglion cell (RGC) survival and degeneration, including that associated with glaucoma. IL-6 protects RGCs from pressure-induced apoptosis
Cory Chew et al.
Neurorehabilitation and neural repair, 33(8), 656-667 (2019-07-10)
Background. Motoneuron loss is a severe medical problem that can result in loss of motor control and eventually death. We have previously demonstrated that partial motoneuron loss can result in dendritic atrophy and functional deficits in nearby surviving motoneurons, and
資料
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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