由来生物
goat
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
lyophilized powder
化学種の反応性
mouse
テクニック
indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL
UniProtアクセッション番号
保管温度
−20°C
遺伝子情報
mouse ... Tnfsf8(21949)
詳細
CD30 Ligand (CD30L) is a type II membrane glycoprotein of the tumor necrosis factor (TNF) superfamily. It is expressed on the cell surface of activated T cells, B cells, and monocytes. CD30L is also present in other cells, including mature dendritic cells, macrophages and mast cells. CD30L is also reffered to as Tnfsf8 (Tumor necrosis factor ligand superfamily member 8).
免疫原
purified recombinant mouse CD30 ligand (amino acids 68-239) extracellular domain, expressed in NSO cells.
アプリケーション
Anti-CD30 antibody produced in goat is suitable for indirect ELISA at a concentration of 0.5-1.0μg/mL and western blotting at a concentration of 0.1-0.2μg/mL.
生物化学的／生理学的作用
CD30L (CD30 ligand) along with CD30 is involved in activation and proliferation of T and B cells. They are also involved in the regulation of initial artherosclerosis development. CD30L/CD30 is crucial for maintenance and activation of IL (Interleukin)-17A-producing γδ T cells. CD30L/CD30 causes down-regulation of IL-2, resulting in Th17 differentiation of CD4+ T cells. CD30L helps in memory phenotype CD4+ T cells-mediated protection against infection with Listeria monocytogenes. CD30L/CD30 signaling is critical for Th1 response against Mycobacterium bovis bacillus Calmette-Guérin (BCG) infection. They are also linked to allergic rhinitis pathogenesis in mice. CD30L/CD30 signaling is involved in pathogenesis of inflammatory bowel diseases.
物理的形状
凍結乾燥品(0.2 μmフィルターろ過済みPBS溶液)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
適切な製品が見つかりませんか。
製品選択ツール.をお試しください
保管分類コード
13 - Non Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
C5612-BULK:
C5612-100UG:
C5612-VAR:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
X Sun et al.
Mucosal immunology, 6(6), 1191-1201 (2013-04-04)
CD30 ligand (CD30L, CD153), a member of the tumor necrosis factor (TNF) superfamily, and its receptor CD30 are important for differentiation and activation of CD4(+) T helper type 17 (Th17) cells. In this report, we demonstrate that the interleukin 17A
H J Gruss et al.
The American journal of pathology, 149(2), 469-481 (1996-08-01)
The CD30 ligand (CD30L) is a type II transmembrane glycoprotein of the tumor necrosis factor ligand superfamily. Recent cloning of CD30L has enabled studies to explore its function and tissue distribution. For instance, recombinant CD30L has been shown to co-stimulate
Takafumi Fuchiwaki et al.
European journal of immunology, 41(10), 2947-2954 (2011-07-09)
CD30 ligand (CD30L) plays an important role in the amplification and/or activation of effector CD4(+) T cells, irrespective of Th cell subset. To examine the role of CD30L in allergic rhinitis, we evaluated an OVA model of allergic rhinitis in
Ce Tang et al.
Journal of immunology (Baltimore, Md. : 1950), 181(9), 6316-6327 (2008-10-23)
A CD30 ligand (CD30L, CD153) is a type II membrane-associated glycoprotein belonging to the TNF family. To illustrate the potential role of CD30L in CD4(+) Th1 cell responses, we investigated the fate of Ag-specific CD4(+) T cells in CD30L-deficient (CD30L(-/-))
Xun Sun et al.
Gastroenterology, 134(2), 447-458 (2008-02-05)
A CD30-ligand (CD30L) is a 40-kilodalton, type II membrane-associated glycoprotein belonging to the tumor necrosis factor family. Serum levels of soluble CD30 increased in inflammatory bowel diseases (IBD), suggesting that CD30L/CD30 signaling is involved in the pathogenesis of IBD. In
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）