C4490

抗カベオリン1 ウサギ宿主抗体

affinity isolated antibody, buffered aqueous solution

• 別名: 抗カベオリン1, 抗VIP21抗体
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD01633097
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IF, WB
• Citations: 17

特性

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 22 kDa
• species reactivity: human, rat, mouse
• technique(s): indirect immunofluorescence: 4-8 μg/mL using HUVEC cell line, indirect immunofluorescence: suitable, western blot: 1-2 μg/mL using whole cell extract of the human endothelial ECV304 cell line and the mouse fibroblast NIH3T3 cell line
• UniProt accession no.: Q03135
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CAV1(857) ; mouse ... Cav1(12389) ; rat ... Cav1(25404)

詳細

General description

Caveolin, a 20-24 kDa integral transmembrane protein, has been identified as a principal component of caveolae membranes. Caveolin (also termed VIP21) exists in several isoforms termed caveolin-1, caveolin-2 and caveolin-3. Caveolin-1 (CAV1) (20- 22 kDa) can exist as two isoforms, caveolin-1α and -1β due to alternative splicing of the mRNA. Caveolin-1 and -2 have similar tissue distribution.

Immunogen

ヒトカベオリン-1のN末端領域(アミノ酸2-20)に相当する合成ペプチド。

Application

Anti-Caveolin-1 antibody produced in rabbit has been used in:

• immunoblotting
• immunofluorescence
• immunohistochemistry[1]

Biochem/physiol Actions

この配列はラット, マウス, ウシ, イヌのカベオリン-1と同一であり、多くの生物種で高度に保存されています。また、この配列はカベオリン-2, カベオリン-3には存在しません。

Caveolin can simultaneously recognize GPI-linked proteins and interact directly with a number of caveolae associated downstream signaling molecules, such as H-Ras, hetero-trimeric G-proteins, annexin-II, epidermal growth factor receptor (EGFR), protein kinase C, src-family tyrosine kinases and nitric oxide synthase (NOS) isoforms. Caveolin-1 participates in angiogenesis and is expected to play a major role in the growth and evolution of cancer. It participates in glucose metabolism by controlling the expression of glucose transporters.

Physical form

0.01M PBS溶液 (pH 7.4, 15mMアジ化ナトリウム含有)。

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類: 12 - Non Combustible Liquids
• wgk: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable