由来生物
rabbit
結合体
unconjugated
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
分子量
antigen ~28 kDa
化学種の反応性
human
テクニック
western blot: 1:500-1:2,000
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... CLIC2(1193)
詳細
Chloride intracellular channel protein 2 is a protein encoded by the CLIC2 gene in humans and belongs to chloride intracellular channel (CLIC) family. It is also referred as CLIC2b, MRXS32 and XAP121. CLIC2 protein is a member of the glutathione transferase class of proteins and they can exist as integral membrane-channel form or a soluble form. The gene is possibly associated with one of the many diseases linked to Xq28.
免疫原
synthetic peptide corresponding to amino acids 233-247 of human CLIC2
アプリケーション
Anti-CLIC2 (233-247) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
生物化学的／生理学的作用
Chloride intracellular channel 2 (CLIC2) functions by regulating ryanodine receptor (RyR) intracellular Ca(2+) release channels. RyR proteins play a major role in the regulation of Ca(2+) signaling in many cells. CLIC2 protein also helps in maintaining normal cognitive function by interacting with RyRs in the brain. In healthy individuals it is studied that the CLIC2 protein can tolerate amino acid substitutions and can be fully functional.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Kyoko Takano et al.
Human molecular genetics, 21(20), 4497-4507 (2012-07-21)
Chloride intracellular channel 2 (CLIC2) protein is a member of the glutathione transferase class of proteins. Its' only known function is the regulation of ryanodine receptor (RyR) intracellular Ca(2+) release channels. These RyR proteins play a major role in the
N S Heiss et al.
Genomics, 45(1), 224-228 (1997-10-27)
A transcript map was previously constructed in the 1200-kb telomeric region of Xq28. One of the cDNAs, XAP121, displayed homology to a p64 bovine chloride channel and to a human chloride channel (p64CLCP, NCC27) at both the nucleotide and the
Brett A Cromer et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 63(Pt 11), 961-963 (2007-11-17)
The chloride intracellular channel (CLIC) family of proteins are unusual in that they can exist in either an integral membrane-channel form or a soluble form. Here, the expression, purification, crystallization and preliminary diffraction analysis of CLIC2, one of the least-studied
Shawn Witham et al.
Proteins, 79(8), 2444-2454 (2011-06-02)
Large-scale next generation resequencing of X chromosome genes identified a missense mutation in the CLIC2 gene on Xq28 in a male with X-linked intellectual disability (XLID) and not found in healthy individuals. At the same time, numerous nsSNPs (nonsynonomous SNP)
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