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由来生物
rabbit
品質水準
抗体製品の状態
Ig fraction of antiserum
クローン
monoclonal
詳細
For In Vitro Diagnostic Use in Select Regions (See Chart)
形状
buffered aqueous solution
テクニック
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
輸送温度
wet ice
保管温度
2-8°C
視覚化
(nuclear,cytoplasm)
詳細
P62, also known as Sequestosome-1, is a ubiquitin-binding adapter protein involved in the delivery of ubiquitin-bound protein and organelles to the autophagosome for lysosomal degradation during autophagy. Mutations in p62 have been linked to Paget′s disease and neurodegenerative disorders. P62 is typically degraded during the autophagy process, but can accumulate and/or overexpressed in autophagy-deficient cells. Presence of p62 cytosolic aggregate is used as a marker for autophagy deficiency. Defective autophagy increase oxidative stress and may play a role in tumorigenesis. P62 immunohistochemistry (IHC) diagnostic utility was established for identifying hepatocellular carcinoma (HCC). P62 demonstrates superior sensitivity for HCC compared against glypican-3. Positive p62 staining was found in 100% of HCC but were negative in all non-tumor areas and cirrhotic nodules. Furthermore, a panel consisting of p62, aminoacylase 1, and glypican-3 provides high sensitivity (93.8%) and specificity (95.2%) in the differential diagnosis between well differentiated HCC and high grade dysplastic nodules. P62 expression can also aid in diagnosing drug-induced autophagic vacuolar myopathies. An optimal threshold of at least 11.5% positive fibers provided 100% sensitivity and 100% specificity for autophagic myopathy. While current diagnostic criteria require identification of autophagic vacuoles by electron microscopy, diagnosis with p62 IHC could expedite the process and reduce costliness and large sampling variance associated with electron microscopy.
品質
 IVD |  IVD |  IVD |  RUO |
物理的形状
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
その他情報
For a copy of the IFU and CofA contact IVDorder@ABCAM.com
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
AC-0368A:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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