AC-0351

Claudin-1 (EP420) Rabbit Monoclonal Primary Antibody

• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 500
• 抗体製品の状態: Ig fraction of antiserum
• クローン: monoclonal
• 詳細: For In Vitro Diagnostic Use in Select Regions (See Chart)
• 形状: buffered aqueous solution
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
• 輸送温度: wet ice
• 保管温度: 2-8°C
• 視覚化: (membrane/cytoplasm)

詳細

詳細

Claudin-1 (CLDN-1) is a member of the claudin integral membrane tight junction protein family. Claudins are responsible for regulating paracellular permeability, promoting cell adhesion and maintaining cell polarity and barrier function. Localized to the cytosol and membrane, Claudin-1 is broadly expressed in most tissues and is localized to most epithelial cells. Surrounding secretory epithelial cells of stroma components such as fibroblasts, pneumocytes and lymphocytes do not express Claudin-1. Claudin-1 expression is typically reduced in proliferating compared to quiescent epithelial cells. Claudin-1 was immuno-negative in 98% of prostate cancer cases and significantly decreased in colon carcinoma tissue compared to adjacent normal mucosa. Furthermore, Claudin-1 has demonstrated utility for identifying squamous cell carcinomas (SqCC). In lung tumors, Claudin-1 expression was detected in 78% of SqCC but only 17% of adenocarcinoma. Its upregulation is observed in pancreatic, thyroid, lung and oral SqCC.

品質

IVD

IVD

IVD

RUO

物理的形状

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and &< 0.1%Sodium Azide

その他情報

For a copy of the IFU and CofA contact IVDorder@ABCAM.com

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安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable