A0233
AS605240
≥98% (HPLC)
別名:
5-(6-キノキサリニルメチレン)-2,4-チアゾリジンジオン
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| あなたへ/カタログ番号 | 在庫状況 | 単価 |
|---|---|---|
5 mg | カートの在庫状況を確認する | ￥20,900 |
25 mg | カートの在庫状況を確認する | ￥74,400 |
この商品について
実験式（ヒル表記法）:
C12H7N3O2S
CAS番号:
分子量:
257.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
, faint red to orange to dark brown
solubility
DMSO: 1 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
O=C1NC(=O)C(\S1)=C\c2ccc3nccnc3c2
InChI
1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6-
InChI key
SQWZFLMPDUSYGV-POHAHGRESA-N
Application
Biochem/physiol Actions
AS605240は、PI3Kγに対する強力かつ選択的なインヒビターです。
AS605240 inhibits human recombinant phosphatidylinositol 3-kinase (PI3K) γ, α, β, and δ by competing with adenosine triphosphate (ATP).[4] It plays a role in protecting injury following ischemic stroke. AS605240 also inhibits the activation of astrocytes under the influence of Interleukin-6 (IL-6) and its soluble receptor (sIL-6R).[5] It reduces collagen deposition and prevents lung inflammation. AS605240 also inhibits the increase of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression instigated by bleomycin. It is effective in preventing pulmonary fibrosis by inhibiting the transforming growth factor β1 (TGF-β1) and T lymphocytes infiltration into lungs.[4]
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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当該品目 | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility DMSO: 1 mg/mL, clear (warmed) | solubility DMSO: 5 mg/mL, clear | solubility DMSO: 25 mg/mL, clear | solubility DMSO: 20 mg/mL, clear |
| color , faint red to orange to dark brown | color off-white to brown | color white to beige | color white to beige |
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves