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由来生物
rabbit
品質水準
100
500
結合体
unconjugated
抗体製品の状態
culture supernatant
抗体製品タイプ
primary antibodies
クローン
EP206, monoclonal
詳細
(For In Vitro Diagnostic Use in Select Regions (See Chart))
フォーム
buffered aqueous solution
交差性
human
包装
bottle of 1.0 mL predilute (437R-17)
bottle of 7.0 mL predilute (437R-18)
vial of 0.1 mL concentrate (437R-14)
vial of 0.5 mL concentrate (437R-15)
vial of 1.0 mL concentrate (437R-16)
メーカー/製品名
Cell Marque®
テクニック
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
アイソタイプ
IgG
輸送温度
wet ice
保管温度
2-8°C
遺伝子情報
human ... ITGAE(3682)
詳細
CD103 is an integrin subunit, αE, encoded by the ITGAE gene on chromosome 17.2 CD103 is expressed in almost all cases of hairy cell leukemia (HCL) and absent in the majority of other B-cell neoplasms with an exception to splenic marginal zone lymphoma, in which rare cases express CD103.1,2 CD103 has been found in mononuclear cells in the interfollicular area of lymph nodes and in intraepithelial cells in the overlying mucosa located primarily toward the basal layer of the tonsil.2 The high sensitivity of anti-CD103 for hairy cell leukemia makes this marker valuable when distinguishing from other B-cell neoplasms.
品質
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関連事項
CD103 Positive Control Slides, Product No. 437S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
物理的形状
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
調製ノート
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
その他情報
For Technical Service please contact: 800-665-7284 or email: [email protected]
法的情報
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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試験成績書(COA)
Lot/Batch Number
Elizabeth A Morgan et al.
American journal of clinical pathology, 139(2), 220-230 (2013-01-29)
Detection of the integrin subunit CD103 is a useful diagnostic tool in the diagnosis of hairy cell leukemia (HCL). Currently, flow cytometric analysis (FC) and frozen section immunohistochemistry (IHC) represent the only available methods of detection. This study is the
Henry Y Dong et al.
American journal of clinical pathology, 131(4), 586-595 (2009-03-18)
CD103 is characteristically expressed in hairy cell leukemia (HCL), a B-lymphoproliferative disorder highly responsive to treatment with purine analogs. Other CD103+ diseases are rare and do not respond well to the same therapy, including HCL variant (HCLv) and splenic marginal
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