おすすめの製品
無菌性
Filtered sterilized solution
形状
aqueous solution
分子量
~23.0 kDa
包装
pkg of 10 mg
濃度
1.0 mg/mL protein
テクニック
cell culture | mammalian: suitable
結合特異性
Receptor: α2β1
Domain: α1(I)
Binding Motif: DGEA
輸送温度
ambient
保管温度
2-8°C
アプリケーション
MAPTrix™ Technology provides a true extracellular microenvironment (ECM) by presenting combinatorial peptide motifs. The ECM, defined by biochemical cues and physical cues, is a deciding factor in a wide range of cellular processes including cell adhesion, proliferation, differentiation, and expression of phenotype-specific functions.Currently existing technology offers simple and merely adequate environments that facilitate simple cell processes such as cellular adhesion. The simple presentation of cell adhesion motifs is not optimal for controlling more integrated processes. Crosstalk among signaling pathways act synergistically to enhance cellular responses such as cell adhesion or proliferation. A study showed that a combination of extracellular matrix derived peptides presented on a surface may enhance cell adhesion strength and focal adhesion assembly. The combinatorial presentation of ECM peptides on cell growth surfaces may also promote elevated proliferation rates of primary or stem cells.
特徴および利点
- Biochemically-defined, animal-free cell culture surfaces designed to enhance cell performance
- MAPTrix™ produces a uniform ECM surface that provides a highly controlled 2D extracellular microenvironment for cell cultures and related applications
- Adhesion properties of the mussel adhesive protein makes the coating reproducible & reliable
法的情報
MAPTrix is a trademark of Kollodis Biosciences
保管分類コード
10 - Combustible liquids
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
165064K-10MG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
S J Fashena et al.
Nature cell biology, 2(12), E225-E229 (2001-01-09)
Over the past twenty years, intensive research has enabled us to identify components of specific signalling pathways downstream of an array of adhesion and growth-factor receptors. The first Gordon Research Conference on 'Signalling by Adhesion Receptors', which took place in
Catherine D Reyes et al.
Journal of cellular physiology, 217(2), 450-458 (2008-07-10)
Cell adhesion to extracellular matrix (ECM) components through cell-surface integrin receptors is essential to the formation, maintenance and repair of numerous tissues, and therefore represents a central theme in the design of bioactive materials that successfully interface with the body.
Seung Tae Lee et al.
Biomaterials, 31(6), 1219-1226 (2009-11-21)
We present development and use of a 3D synthetic extracellular matrix (ECM) analog with integrin-specific adhesion ligands to characterize the microenvironmental influences in embryonic stem cell (ESC) self-renewal. Transcriptional analysis of 24 integrin subunits followed by confirmation at the translational
Stephanie J Ellis et al.
Cell and tissue research, 339(1), 121-130 (2009-07-10)
The regulation of stem cell behavior and maintenance typically involves the integration of both intrinsic and extrinsic cues. One such external cue, integrin-mediated cell adhesion to the extracellular matrix, plays an important part in regulating stem cell function and maintenance.
Ying Meng et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(4), 1056-1065 (2009-11-26)
Human embryonic stem (hES) cells are pluripotent, capable of differentiating into any cell type of the body, and therefore have the ability to provide insights into mechanisms of human development and disease, as well as to provide a potentially unlimited
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