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Merck

03716

Supelco

(±)-Lisofylline

analytical standard

別名:

Lisofylline, (±)-1-(5-Hydroxyhexyl)-3,7-dimethylxanthine, 5-Hydroxy pentoxifylline, Penthydroxyfylline

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About This Item

実験式(ヒル表記法):
C13H20N4O3
CAS番号:
分子量:
280.32
MDL番号:
UNSPSCコード:
41116107
PubChem Substance ID:
NACRES:
NA.24

グレード

analytical standard

品質水準

アッセイ

≥99.0% (HPLC)

シェルフライフ

limited shelf life, expiry date on the label

テクニック

HPLC: suitable
gas chromatography (GC): suitable

アプリケーション

forensics and toxicology
pharmaceutical (small molecule)

フォーマット

neat

保管温度

−20°C

SMILES記法

O=C1N(CCCCC(O)C)C(N(C)C2=C1N(C)C=N2)=O

InChI

1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3

InChI Key

NSMXQKNUPPXBRG-UHFFFAOYSA-N

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詳細

Lisofylline (LSF) is a synthetically modified methylxanthine which is known to exhibit various therapeutic properties. It is a potent anti-inflammatory agent and an antioxidant with the ability to suppress oxygen radical production. LSF is used for treating acute lung injury and also has a role in the early treatment of diabetes.

アプリケーション

Lisofylline may be used as an analytical reference standard for the determination of the analyte in rat plasma by various high-performance liquid chromatography (HPLC) based techniques.

おすすめ製品

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保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


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Lisofylline, a novel antiinflammatory agent, protects pancreatic $\beta$-cells from proinflammatory cytokine damage by promoting mitochondrial metabolism
Chen M, et al.
Endocrinology, 143(6), 2341-2348 (2002)
Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes
Yang Z, et al.
Biochemical and Biophysical Research Communications, 344(3), 1017-1022 (2006)
Lisofylline: a potential lead for the treatment of diabetes
Yang Z, et al.
Biochemical Pharmacology, 69(1), 1-5 (2005)
Simultaneous estimation of lisofylline and pentoxifylline in rat plasma by high performance liquid chromatography-photodiode array detector and its application to pharmacokinetics in rat
Italiya KS, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1061(1), 49-56 (2017)
Validation of a high
Walczak M, et al.
Acta Poloniae Pharmaceutica, 66(3), 215-224 (2009)

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