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product name
DC2.4 Mouse Dendritic Cell Line, DC2.4 dendritic cell line can be used to study dendritic cell biology and immune response.
由来生物
mouse
品質水準
テクニック
cell culture | mammalian: suitable
詳細
.4 are immortalized murine dendritic cells created by transducing bone marrow isolates of C57BL/6 mice with retrovirus vectors expressing murine granulocyte-macrophage CSF (GM-CSF) and the myc and raf oncogenes . DC2.4 exhibits characteristic features of dendritic cells including cell morphology and the expression of dendritic cell-specific markers and the ability to phagocytose and present exogenous antigens on both MHC class I and class II molecules .
Dendritic cells (DC) are the antigen presenting cells of the immune system and are found in most tissues, particularly those that are in contact with the external environment (e.g., skin and the inner linings of the nose, lungs, stomach and intestine). First described in 1973 , one of the primary functions of DCs is to phagocytose foreign pathogens and present the processed antigens to naïve T cells to regulate adaptive immune responses. DCs also express Toll-like receptors and help regulate the innate immune responses. Despite their distribution in most tissues, DC are present at low numbers in vivo and are difficult to maintain in vitro. These difficulties have limited the studies of dendritic cells.
細胞株の説明
Dendritic Cell Line
アプリケーション
Research Category
免疫応答
炎症及び免疫
免疫応答
炎症及び免疫
This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the "Academic Use Agreement" as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
品質
• Each vial contains ≥ 1X106 viable cells.
• Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
保管および安定性
Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SCC142:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
R M Steinman et al.
The Journal of experimental medicine, 137(5), 1142-1162 (1973-05-01)
A novel cell type has been identified in adherent cell populations prepared from mouse peripheral lymphoid organs (spleen, lymph node, Peyer's patch). Though present in small numbers (0.1-1.6% of the total nucleated cells) the cells have distinct morphological features. The
Z Shen et al.
Journal of immunology (Baltimore, Md. : 1950), 158(6), 2723-2730 (1997-03-15)
Pathways for presenting proteins from the extracellular fluids on MHC class I molecules have been described in macrophages. However, it is uncertain whether similar mechanisms exist in dendritic cells, because conventional preparations of these cells can be contaminated with macrophages.
Vinit Sheth et al.
ACS nano, 17(9), 8376-8392 (2023-04-19)
Super-resolution microscopy can transform our understanding of nanoparticle-cell interactions. Here, we established a super-resolution imaging technology to visualize nanoparticle distributions inside mammalian cells. The cells were exposed to metallic nanoparticles and then embedded within different swellable hydrogels to enable quantitative
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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