MABS1816

Anti-LRIG1 Antibody, clone 2D1.1

clone 2D1.1, from mouse

• 別名: Leucine-rich repeats and immunoglobulin-like domains protein 1, LIG-1
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 2D1.1, monoclonal
• 化学種の反応性: human
• 包装: antibody small pack of 25 μg
• テクニック: western blot: suitable
• アイソタイプ: IgG1κ
• NCBIアクセッション番号: NP_056356
• UniProtアクセッション番号: Q96JA1
• 輸送温度: ambient
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... LRIG1(26018)

詳細

詳細

Leucine-rich repeats and immunoglobulin-like domains protein 1 (UniProt: Q96JA1; also known as LIG-1) is encoded by the LRIG1 (also known as LIG1) gene (Gene ID: 26018) in human. LIG-1 is a widely expressed single-pass type I membrane protein that acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. LIG-1 contains 3 Ig-like C2-type (immunoglobulin-like) domains, 15 LRR (leucine-rich) repeats, 1 1 LRRCT domain, and 1LRRNT domain. The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding and this interaction is abolished only when these two domains are deleted. LIG-1 is highly expressed by intestinal stem cells and controls the size of the intestinal stem-cell niche by regulating the amplitude of growth-factor signaling. It is also reported to control stem-cell proliferation in epidermis. LIG-1 is reported to be expressed in a gradient with highest levels in intestinal stem cells and it is absent from Paneth cells. About one-third of all cells in the intestinal crypts are shown to express LIG-1. (Ref.: Wong VWY., et al. (2012). Nat. Cell Biol. 14(4); 401-408).

特異性

Clone 2D1.1 detects Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) in human. It targets an epitope within 134 amino acids from the C-terminal end.

免疫原

GST/His-tagged recombinant fragment corresponding to 134 amino acids from the C-terminal end of human Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1).

アプリケーション

Research Category
細胞シグナル伝達

Anti-LRIG1 Antibody, clone 2D1.1, Cat. No. MABS1816, is a mouse monoclonal antibody that targets human Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) and has been tested for use in Western Blotting.

品質

Evaluated by Western Blotting in LNCaP cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected LRIG1 in 10 µg of LNCaP cell lysate.

ターゲットの説明

~150 kDa observed; 119.11 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

物理的形状

Protein G purified

Format: Purified

Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1