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由来生物
rabbit
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
2A3/2E6, monoclonal
化学種の反応性
human
化学種の反応性（ホモロジーによる予測）
all (based on 100% sequence homology)
テクニック
immunocytochemistry: suitable
western blot: suitable
アイソタイプ
IgG
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... UBAP2(55833)
詳細
Recently, the lysine11 (K11) linkage of ubiquitin has been shown to be specifically targeted by the Anaphase-Promoting Complex (APC) E3 ubiquitin ligase for catalyzed ubiquitination for mitosis. Antibodies specific to the K11-linkage have shown that the formation of the K11 chains are greatly increased in mitotic human cells in the presence of APC substrate degradation. K11-linked ubiquitin chains seem to have essential regulatory control over mitotic protein degradation.
免疫原
Recombinant protein corresponding to all in Ubiquitin K11 linkage.
アプリケーション
Research Category
細胞シグナル伝達
細胞シグナル伝達
Research Sub Category
発生シグナル伝達
発生シグナル伝達
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Ubiquitin K11 linkage in A431 and HeLa cells.
This Anti-Ubiquitin K11 linkage Antibody, clone 2A3/2E6 is validated for use in western blotting & ICC for the detection of Ubiquitin K11 linkage.
品質
Evaluated by Western Blotting in K11 recombinant protein.
Western Blotting Analysis: A 1:250 to 1:1,000 dilution of this antibody detected Ubiquitin K11 linkage in 10 µg of K11 recombinant protein.
Western Blotting Analysis: A 1:250 to 1:1,000 dilution of this antibody detected Ubiquitin K11 linkage in 10 µg of K11 recombinant protein.
ターゲットの説明
Varies
物理的形状
Protein A purified
Format: Purified
Purified rabbit monoclonal IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
保管および安定性
Stable for 1 year at 2-8°C from date of receipt.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
MABS107-I:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Mingwei Min et al.
Molecular biology of the cell, 26(24), 4325-4332 (2015-10-09)
The ubiquitin proteasome system (UPS) directs programmed destruction of key cellular regulators via posttranslational modification of its targets with polyubiquitin chains. These commonly contain Lys-48 (K48)-directed ubiquitin linkages, but chains containing atypical Lys-11 (K11) linkages also target substrates to the
Michael E French et al.
The Journal of biological chemistry, 292(25), 10398-10413 (2017-05-04)
Homologous to E6AP C-terminal (HECT) ubiquitin (Ub) ligases (E3s) are a large class of enzymes that bind to their substrates and catalyze ubiquitination through the formation of a Ub thioester intermediate. The mechanisms by which these E3s assemble polyubiquitin chains
Rahul S Samant et al.
Nature, 563(7731), 407-411 (2018-11-16)
Protein misfolding is linked to a wide array of human disorders, including Alzheimer's disease, Parkinson's disease and type II diabetes1,2. Protective cellular protein quality control (PQC) mechanisms have evolved to selectively recognize misfolded proteins and limit their toxic effects3-9, thus
Swarna L Vijayaraj et al.
Nature communications, 12(1), 2713-2713 (2021-05-13)
Interleukin-1β (IL-1β) is activated by inflammasome-associated caspase-1 in rare autoinflammatory conditions and in a variety of other inflammatory diseases. Therefore, IL-1β activity must be fine-tuned to enable anti-microbial responses whilst limiting collateral damage. Here, we show that precursor IL-1β is
Animesh Dhara et al.
mSphere, 1(3) (2016-06-25)
The contribution of ubiquitin-mediated mechanisms in the regulation of the Toxoplasma gondii cell cycle has remained largely unexplored. Here, we describe the functional characterization of a T. gondii deubiquitinase (TGGT1_258780) of the ovarian-tumor domain-containing (OTU) family, which, based on its structural
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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