MABN355

Anti-HAND2 Antibody, Clone 7D4.1

clone 7D4.1, from mouse

• 別名: Heart- and neural crest derivatives-expressed protein 2, Class A basic helix-loop-helix protein 26, bHLHa26, Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, dHAND
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 7D4.1, monoclonal
• 化学種の反応性: human, mouse
• テクニック: immunohistochemistry: suitable; western blot: suitable
• アイソタイプ: IgG1κ
• NCBIアクセッション番号: NP_068808
• UniProtアクセッション番号: P61296
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... HAND2(9464)

詳細

詳細

Heart-and neural crest derivatives-expressed protein 2 , also known as Class A basic helix-loop-helix protein 26 (bHLHa26), or Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), and encoded by the gene HAND2/BHLHA26/DHAND, is a transcription factor that is essential for cardiac morphogenesis, particularly the formation of the right ventricle and the aortic arch arteries. Heart-and neural crest derivatives-expressed protein 2 is required for vascular development, angiogenesis and for limb development acting upstream of sonic hedgehog in the induction of the limb bud. Additionally, Heart-and neural crest derivatives-expressed protein 2 is central to cardiac neural crest cell development and involved in outflow tract morphogenesis as well as the maintenance of the adult heart and in the negative regulation of cardiac muscle cell apoptosis. Heart-and neural crest derivatives-expressed protein 2 is localized to the nucleus. Heart-and neural crest derivatives-expressed protein 2 is expressed in developing heart, lung and vascular system.

免疫原

Epitope: C-terminus outside the bHLH domain

Recombinant protein corresponding to the C-terminus outside the bHLH domain of human HAND2.

アプリケーション

Detect HAND2 using this Anti-HAND2 Antibody, Clone 7D4.1 validated for use in western blotting & IHC.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected HAND2 in human placenta tissue.

品質

Evaluated by Western Blotting in mouse heart tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected HAND2 in 10 µg of mouse heart tissue lysate.

ターゲットの説明

~30 kDa observed

物理的形状

Format: Purified

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable