MABN224

Anti-Thorase Antibody, clone 9G7.1

clone 9G7.1, from mouse

• 別名: ATPase family AAA domain-containing protein 1, Thorase
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 9G7.1, monoclonal
• 化学種の反応性: human
• 化学種の反応性（ホモロジーによる予測）: mouse (based on 100% sequence homology)
• テクニック: western blot: suitable
• アイソタイプ: IgG2bκ
• NCBIアクセッション番号: NP_116199
• UniProtアクセッション番号: Q8NBU5
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ATAD1(84896)

詳細

詳細

Thorase is an ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Thorase thus helps mediate synaptic plasticity and learning and memory. Thorase expression is required for NMDA-stimulated AMPAR internalization and for the inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane as both of these require ATP processing by Thorase. Thorase is vital for keeping in balance the molecular construction-deconstruction cycle that is required for memory formation. Thorase is one of many AAA+ ATPases that drive the assembly of proteins needed to form specialized receptors at the surfaces of synapses. These receptors are stimulated by neighboring neurons, setting up the signaling and answering connections vital to brain function. Thorase regulates the all-important complementary process of receptor disassembly at synapses, which ultimately tamps down signaling. Thorase is a postsynaptic localized protein, and also is associated with the peroxisome and cell junctions and synapses. Thorase is expressed in the brain and testis primarily.

免疫原

GST-tagged recombinant protein corresponding to human Thorase.

アプリケーション

This Anti-Thorase Antibody, clone 9G7.1 is validated for use in Western Blotting for the detection of Thorase.

Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Thorase in 10 µg of human brain tissue lysate.

品質

Evaluated by Western Blotting in human lymph node tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Thorase in 10 µg of human lymph node tissue lysate.

ターゲットの説明

~41 kDa observed

物理的形状

Format: Purified

その他情報

Concentration: Please refer to lot specific datasheet.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable