MABF536

Anti-CD127 (IL-7Ra) Antibody (mouse), Biotin, clone A7R34

clone A7R34, 0.5 mg/mL, from rat

• 別名: Interleukin-17 receptor A, IL-17 receptor A, IL-17RA, CD217
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rat
• 品質水準: 100
• 結合体: biotin conjugate
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: A7R34, monoclonal
• 化学種の反応性: mouse
• 包装: antibody small pack of 25 μg
• 濃度: 0.5 mg/mL
• テクニック: flow cytometry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable
• アイソタイプ: IgG2aκ
• UniProtアクセッション番号: Q60943
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: mouse ... Il7R(16197)

詳細

詳細

The A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.The A7R34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM).

This rat monoclonal antibody Anti-CD127 (IL-7Ra) (mouse), Biotin, clone A7R34 validated for use in IP, Flow Cytometry & IHC for the detection of CD127 (IL-7Ra).

品質

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.06 µg of this antibody detected CD127 (IL-7Ra) in one million C57Bl/6 splenocytes.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable