おすすめの製品
詳細
Chemicon Investigator Kits for Integrin Research are a cost-effective source of reagents for all investigators intimately involved with this expanding field of study. The Collagen-Specific Integrins Investigator Kit is designed for research focused on integrins which interact with members of the collagen family of proteins. Collagen-specific integrins include: alpha1, alpha2, and alpha3 subunits, which pair with the integrin beta1 subunit, and alphaV, which pairs with beta3 [Hynes, R. 1992. Cell 69: 11-25].
Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.
Chemicon offers the Collagen-Specific Integrins Investigator Kit for studies of collagen/integrin interactions. All kit reagents are also available in larger sizes. The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator.
Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.
Chemicon offers the Collagen-Specific Integrins Investigator Kit for studies of collagen/integrin interactions. All kit reagents are also available in larger sizes. The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator.
構成
alpha1 Mouse Monoclonal Antibody (Part No. MAB1973Z-20) - 1 tube, 20 μg.
alpha2 Mouse Monoclonal Antibody (Part No. MAB1950Z-20)- 1 tube, 20 μg.
alpha3 Mouse Monoclonal Antibody (Part No. MAB2056-20) - 1 tube, 20 μg.
alphaV Mouse Monoclonal Antibody (Part No. MAB1953Z-20)- 1 tube, 20 μg.
beta1 Mouse Monoclonal Antibody (Part No. MAB1951Z-20) - 1 tube, 20 μg.
beta3 Monoclonal Antibody (Part No. MAB1957Z-20) - 1 tube, 20 μg.
alphaVbeta3 Mouse Monoclonal Antibody (Part No. MAB1976Z-20)- 1 tube, 20 μg.
alpha2 Mouse Monoclonal Antibody (Part No. MAB1950Z-20)- 1 tube, 20 μg.
alpha3 Mouse Monoclonal Antibody (Part No. MAB2056-20) - 1 tube, 20 μg.
alphaV Mouse Monoclonal Antibody (Part No. MAB1953Z-20)- 1 tube, 20 μg.
beta1 Mouse Monoclonal Antibody (Part No. MAB1951Z-20) - 1 tube, 20 μg.
beta3 Monoclonal Antibody (Part No. MAB1957Z-20) - 1 tube, 20 μg.
alphaVbeta3 Mouse Monoclonal Antibody (Part No. MAB1976Z-20)- 1 tube, 20 μg.
物理的形状
For the study of collagen-associated integrins. With Chemicon′s Collagen Specific Integrins Investigator Kit (ECM425) researchers are provided with 20 μg each of monoclonals to alpha1, alpha2, alpha3, alphaV, alphaVbeta3, beta1, and beta3.
保管および安定性
Store antibodies at -20°C.
Important Note: Due to the small volumes contained within the kit, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge before opening to dislodge any liquid entrapped in the container′s cap during shipment.
Important Note: Due to the small volumes contained within the kit, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge before opening to dislodge any liquid entrapped in the container′s cap during shipment.
法的情報
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類コード
10 - Combustible liquids
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
ECM425:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Three-dimensional collagen fiber remodeling by mesenchymal stem cells requires the integrin-matrix interaction.
Ching-Fang Chang,Ming-Wei Lee,Pei-Yin Kuo,Yng-Jiin Wang,Yi-Hsien Tu,Shih-Chieh Hung
Journal of Biomedical Materials Research Part A null
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）