ABT342

Anti-ADAP Antibody

from rabbit, purified by affinity chromatography

• 別名: ADAP Antibody, Adhesion and degranulation adapter protein, FYN binding protein, FYB-120, 130, SLAP-130, FYN-T-binding protein, SLP-76-associated phosphoprotein
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: human
• テクニック: immunocytochemistry: suitable; western blot: suitable
• UniProtアクセッション番号: O15117
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... FYB(2533)

詳細

詳細

The adhesion and degranulation adaptor protein (ADAP) acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. ADAP modulates the expression of interleukin-2 (IL-2) and it is suggested to be involved in platelet activation. Additionally ADAP is shown to prevent the degradation of SKAP1 and SKAP2 and may play a role in linking T-cell signaling to the remodeling of the actin cytoskeleton. ADAP is expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. At least two isoforms of ADAP are known to exist.

特異性

This antibody recognizes the C-terminus of ADAP.

免疫原

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to the C-terminus of human ADAP.

アプリケーション

Research Category
細胞骨格

Research Sub Category
接着分子（CAM）

Detect ADAP using this rabbit polyclonal antibody, Anti-ADAP Antibody validated for use in western blotting & ICC.

Immunocytochemistry Analysis: 10 µg/mL from a representative lot detected ADAP in K562 cells.

品質

Evaluated by Western Blotting in K562 cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected ADAP in 15 µg of K562 cell lysate.

ターゲットの説明

~130 kDa observed. Uncharacterized bands may appear in some lysates. Uniprot describes 2 isoforms at ~85 kDa and ~91 kDa

物理的形状

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
K562 cell lysate

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable