ABT165

Anti-RAB8A Antibody

from rabbit, purified by affinity chromatography

• 別名: Ras-related protein Rab-8A, Oncogene c-mel
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 交差性: human
• 交差性（ホモロジーによる予測）: mouse (based on 100% sequence homology), bovine (based on 100% sequence homology)
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_005361
• UniProtアクセッション番号: P61006
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... RAB8A(4218) ; mouse ... Rab8A(17274)

詳細

詳細

Ras-related protein Rab-8A (RAB8A) is one of two Rab8 isoforms, which belong to the superfamily of GTPases. They cycle between an active GTP-bound state, formed from interaction with guanine nucleotide exchange factors (GEFs) such as Rabin8 and GRAB; and an inactive GDP-bound state via interaction with GTPase activating proteins (GAPs) such as TBC1D1. Rab8A activates various effector molecules, which are coupled to intracellular signaling networks that mediate membrane and vesicular trafficking, and actin remodeling. Rab8A is found in the golgi network, perinuclear region, plasma membrane, lamellipodia, and cilia, among other regions.

特異性

This antibody recognizes the C-terminus of RAB8A.

免疫原

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to the C-terminus of human RAB8A.

アプリケーション

Research Category
細胞骨格

Research Sub Category
小胞輸送

This Anti-RAB8A Antibody is validated for use in Western Blotting for the detection of RAB8A.

Western Blot Analysis: A representative lot from an independent laboratory detected RAB8A in human cerebellum and brain.

品質

Evaluated by Western Blot in serum starved HeLa cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected RAB8A in serum starved HeLa cell lysate.

ターゲットの説明

~24 kDa observed. Uncharacterized bands may be observed at ~110 kDa and ~38 kDa

物理的形状

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
Serum starved HeLa cell lysate

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable