ABS528

Anti-S1P lyase Antibody

from rabbit, purified by affinity chromatography

• 別名: S1PL, SPL1, mSPL, Sphingosine-1-phosphate aldolase
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: mouse
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_033189
• UniProtアクセッション番号: Q8R0X7
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: mouse ... Sgpl1(20397)

詳細

詳細

S1P lyase is an important enzyme in lipid, steroid, and ceramide metabolism. S1P lyase 1 specifically cleaves phosphorylated sphingoid bases such as sphingosine-1-phosphate into fatty aldehydes and phosphoethanolamine. S1P lyase also plays roles in apoptosis with regards to regulation of ceramide production and plays roles in cell differentiation via its role in androgen and estrogen metabolism as well as that of other important lipids and bioactive lipid derivatives. S1P lyase is expressed in the endoplasmic reticulum in many cells. Interestingly, because Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that promotes cardiomyocyte survival and contributes to ischemic preconditioning, its catabolism by S1P lyase is very important in recovery from heart attacks or other ischemia related events, and thus S1P lyase is being examined as a potential new therapeutic target for reperfusion therapy in heart disease.

免疫原

Epitope: cytoplasmic domain

Linear peptide corresponding to the cytoplasmic domain of Mouse S1P lyase.

アプリケーション

Research Category
細胞シグナル伝達

代謝

Research Sub Category
脂質代謝及びエネルギー調節

脂質シグナル伝達

This Anti-S1P lyase Antibody is validated for use in Western Blotting for the detection of S1P lyase.

Western Blotting Analysis: A representative lot of this antibody detected S1P lyase in 30 μg of lysate from various mice tissues (Bektas, M., et al. (2010). Journal of Biological Chemistry Vol. 285, NO. 14, pp. 10880–10889)

品質

Evaluated by Western Blotting in mouse lung tissue lysate.

Western Blotting Analysis: 1 μg/mL of this antibody detected SP-lyase1 in 10 µg of mouse lung tissue lysate.

ターゲットの説明

~ 56 kDa observed

物理的形状

Antigen Affinity Purified

Purified rabbit polyclonal in buffer with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2