ABN329

Anti-CAPS-1 Antibody

from rabbit, purified by affinity chromatography

• 別名: Calcium-dependent secretion activator 1, CADPS1, CAPS-1
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 交差性: mouse, rat
• 交差性（ホモロジーによる予測）: human (immunogen homology)
• テクニック: immunohistochemistry: suitable; western blot: suitable
• UniProtアクセッション番号: Q9ULU8
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CADPS(8618)

詳細

詳細

CAPS-1 and its related protein CAPS-2 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficient neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. CAPS-1 acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4, 5-bisphosphate and is thought to be a specific regulator of large dense-core vesicle fusion.

特異性

This antibody is predicted to be specific to CAPS-1 and not recognize CAPS-2.

免疫原

KLH-conjugated linear peptide corresponding to human CAPS-1.

アプリケーション

Research Category
ニューロサイエンス

Research Sub Category
ニューロン発生

Anti-CAPS-1 detects levels of CAPS-1 proteins & has been published & validated for use in WB & IHC.

Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected CAPS-1 in rat hippocampus and cerebral cortex tissues.

品質

Evaluated by Western Blot in mouse brain membrane tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected CAPS-1 in 10 µg/mL of mouse brain membrane tissue lysate.

ターゲットの説明

~153 kDa observed. Uncharacterized bands may appear between ~30 kDa and ~110 kDa in some lysates.

物理的形状

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
Mouse brain membrane tissue lysate

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable