ABN117

Anti-PDE4D3 Antibody

from rabbit, purified by affinity chromatography

• 別名: cAMP-specific 3′,5′-cyclic phosphodiesterase 4D, DPDE3, PDE43
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: rat, mouse, rhesus macaque
• 化学種の反応性（ホモロジーによる予測）: human (immunogen homology), rhesus monkey (based on 100% sequence homology)
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_006194
• UniProtアクセッション番号: Q08499
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... PDE4D(5144)

詳細

詳細

Phosphodiesterase 4D3 (PDE4D3) is a member of the PDE cyclic nucleotides. PDE4D3 is known to be regulated by protein kinase C (PKC)-Raf-MEK-ERK and also by cAMP in vascular smooth muscle cells. PDE4D3 is a direct target of the MSH/cAMP/MITF pathway and may play a role in melanocyte differentiation. PDE4D3 is essential to have equilibrium in relaxing and contracting cues to airway smooth muscle. Down-regulation of PDE4D3 may be associated with analgesic and anti-inflammatory effects. PDE4D3 has also been linked to the risk of stroke, and in particular to polygenic stroke.

特異性

This antibody recognizes PDE4D3 at the N-terminus.

免疫原

Epitope: N-terminus

KLH-conjugated linear peptide corresponding to the N-terminus of human PDE4D3.

アプリケーション

Research Category
ニューロサイエンス

Research Sub Category
ニューロン発生

This Anti-PDE4D3 Antibody is validated for use in WB for the detection of PDE4D3.

品質

Evaluated by Western Blot in mouse brain membrane tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected PDE4D3 on 10 µg of mouse brain membrane tissue lysate.

ターゲットの説明

~95 kDa observed. UniProt describes 12 isoforms produced by alternative splicing.

物理的形状

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
Mouse brain membrane tissue lysate

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable