ABE606

Anti-PERP Antibody

from rabbit, purified by affinity chromatography

• 別名: p53 apoptosis effector related to PMP-22, PERP, Keratinocyte-associated protein 1, KCP-1, Krtcap1
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: human
• テクニック: immunocytochemistry: suitable; western blot: suitable
• UniProtアクセッション番号: A6NN79
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... PERP(64065)

詳細

詳細

P53 apoptosis effector related to PMP-22 (PERP), also known as Keratinocyte-associated protein 1 (KCP-1, Krtcap1), is a member of the TMEM47 family and a component of the intercellular desmosome junctions. PERP has been shown to play an important role in the stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Recent evidence implies that PERP is a mediator of p53 induced apoptosis. P53 binds to the promoter of PERP and activates the PERP gene and consequently the translated PERP protein mediates the p53 induced apoptosis. PERP is expressed in apoptotic cells and in the stratified squamous skin epithelium of the skin and the tongue, but not in simple epithelia.

免疫原

KLH-conjugated linear peptide corresponding to human PERP.

アプリケーション

Research Category
エピジェネティクス及び核内機能分子

Research Sub Category
RNA代謝及び結合タンパク質

Detect P53 apoptosis effector related to PMP-22 using this rabbit polyclonal antibody, Anti-PERP Antibody validated for use in western blotting & ICC.

Immunocytochemistry Analysis: 10 µg/mL from a representative lot detected PERP in A431 cells.

品質

Evaluated by Western Blotting/Peptide Inhibition Assay in A431 cell lysate.

Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected PERP in 15 µg of A431 cell lysate.

ターゲットの説明

~21 kDa observed. Uncharacterized bands may appear in some lysate(s).

物理的形状

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
A431 cell lysate

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable