ABE1082

Anti-JARID1C Antibody

from rabbit

• 別名: Lysine-specific demethylase 5C, Histone demethylase JARID1C, Jumonji/ARID domain-containing protein 1C, Protein SmcX, Protein Xe169
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: purified antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 化学種の反応性: human
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_001140174
• UniProtアクセッション番号: P41229
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... KDM5C(8242)

詳細

詳細

JARID1C, also known as Jumonji/ARID domain-containing protein 1C, Protein SmcX, or Protein Xe169, and encoded by the gene KDM5C/DXS1272E/JARID1/SMCX/XE169, a histone demethylase that specifically demethylates ′Lys-4′ of histone H3, thereby playing a central role in histone code. JARID1C demethylates trimethylated and dimethylated but not monomethylated H3 ′Lys-4′. JARID1C does not demethylate histone H3 ′Lys-9′, H3 ′Lys-27′, H3 ′Lys-36′, H3 ′Lys-79′ or H4 ′Lys-20′. Additionally, JARID1C participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. JARID1C is localized to the nucleus. Defects in JARID1C are associated with Mental retardation, X-linked, syndromic, Claes-Jensen type (MRXSCJ) disorder. MRXSCJ patients have below average general intellectual functioning associated with impairments in adaptive behavior during development, and suffer mental retardation, progressive spastic paraplegia, seizures, and facial dysmorphism.

免疫原

Linear peptide corresponding to human JARID1C.

アプリケーション

Research Category
エピジェネティクス及び核内機能分子

Research Sub Category
エピジェネティクス

Anti-JARID1C Antibody detects level of JARID1C & has been published & validated for use in JARID1C.

品質

Evaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected JARID1C in 10 µg of HEK293 cell lysate.

ターゲットの説明

~175 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.

物理的形状

Protein A purified

Format: Purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1