由来生物
rabbit
品質水準
抗体製品の状態
serum
抗体製品タイプ
primary antibodies
クローン
polyclonal
化学種の反応性
rat, mouse, human
テクニック
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... WDR5(11091)
詳細
WD repeat-containing protein 5 (WDR5) or alternatively BMP2-induced 3kb gene protein, is encoded by the human gene named WDR5/BIG3 and is part of a family of WD-40 repeat proteins that appear to facilitate the formation of multi-protein complexes much like a sticky tape will bind a variety of components together. The WD repeat proteins are involved in a wide array of cellular functions and processes including cell cycle progression, homeobox gene activation, apoptosis, gene regulation and histone methylation. One of WDR5 best studied activities is as part of a multi-protein complex that facilitates the methylation of histones, particularly histone H3, through its interaction with MLL a histone methyltransferase. WDR5 is also expressed in developing bone cells including osteoblasts, chondrocytes, and marrow stromal cells and works to accelerate osteoblast differentiation and positively promotes Wnt signaling in developing bone tissues.
免疫原
Linear peptide corresponding to human WD repeat containing protein 5.
アプリケーション
Research Category
エピジェネティクス及び核内機能分子
エピジェネティクス及び核内機能分子
Research Sub Category
エピジェネティクス
エピジェネティクス
This Anti-WD repeat-containing protein 5 antibody is validated for use in western blotting for the detection of WD repeat-containing protein 5.
Western Blotting Analysis: A representative lot from an independent laboratory detected WD repeat containing protein 5 in tested cell lysates. (Wysocka, J., et al. (2003). Genes Dev. 17(7):896-911.; Tyagi, S., et al. (2007). 27(1):107-119.; Jin, S., et al. (2010). J Clin Invest. 120(2):593-606.; Tyagi, S., et al. (2009). EMBO J. 28(20):3185-3195.; Diao, Y., et al. (2012). Cell Stem Cell. 11(2):231-241.; Schram, A. W., et al. (2013). PLoS One. 8(7):e70035.).
品質
Evaluated by Western Blotting in NIH/3T3 cell lysates.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected WD repeat containing protein 5 in 10 µg of NIH/3T3 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected WD repeat containing protein 5 in 10 µg of NIH/3T3 cell lysate.
ターゲットの説明
~37 kDa observed
物理的形状
Unpurified
Rabbit polyclonal serum containing 0.05% sodium azide.
保管および安定性
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
ABE1075:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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