ABC843

Anti-GITRL Antibody

from rabbit, purified by affinity chromatography

• 別名: Tumor necrosis factor ligand superfamily member 18, Activation-inducible TNF-related ligand, AITRL, Glucocorticoid-induced TNF-related ligand, hGITRL
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: human
• テクニック: immunocytochemistry: suitable; western blot: suitable
• UniProtアクセッション番号: Q9UNG2
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TNFSF18(8995)

詳細

詳細

Tumor necrosis factor ligand superfamily member 18, also known as Activation-inducible TNF-related ligand (AITRL) or Glucocorticoid-induced TNF-related ligand (hGITRL) and encoded by the gene name TNFSF18 or AITRL or GITRL or TL6, regulates numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-κB and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells (4) and can activate NF-κB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-κB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.

免疫原

KLH-conjugated recombinant human GITRL ligand.

アプリケーション

Research Category
アポトーシス及び癌

Research Sub Category
アポトーシス-追加

Detect GITRL using this Anti-GITRL Antibody validated for use in western blotting & ICC.

Immunocytochemistry Analysis: 10 μg/mL from a representative lot detected GITRL in THP-1 cells.

品質

Evaluated by Western Blotting in recombinant GITRL protein.

Western Blotting Analysis: 1 μg/mL of this antibody was detected in recombinant GITRL protein.

ターゲットの説明

~26 kDa observed. Uncharacterized bands may be observed in some lysate(s).

物理的形状

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable