ABC839

Anti-ATR Antibody

from rabbit, purified by affinity chromatography

• 別名: Anthrax toxin receptor 1, Tumor endothelial marker 8
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: purified antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: human
• テクニック: immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• UniProtアクセッション番号: Q9H6X2
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ANTXR1(84168)

詳細

詳細

The Anthrax toxin receptor 1 (also known as Tumor endothelial marker 8, ANTXR1 and ATR) was initially discovered as the tumor endothelial marker (TEM8). This protein, which exists in three isoforms (33, 37, 41, and 63 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.

免疫原

Epitope: Center region

KLH-conjugated linear peptide corresponding to 13 amino acids near the center region of human ATR.

アプリケーション

Research Category
アポトーシス及び癌

Research Sub Category
アポトーシス-追加

Anti-ATR Antibody is a highly specific rabbit polyclonal antibody, that targets ATR & has been tested in western blotting, IHC & ICC.

Immunohistochemistry Analysis: 2 μg/mL from a representative lot detected ATR in human brain tissue.

Immunocytochemistry Analysis: 10 μg/mL from a representative lot detected ATR in human brain cells.

品質

Evaluated by Western Blotting in HepG2 cell lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected ATR in HepG2 cell lysate.

ターゲットの説明

~41 kDa observed. Uncharacterized bands may be observed in some lysate(s).

物理的形状

Purified by Ion-Exchange Chromatography

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable