ABC116

Anti-EPS8, Antibody

from rabbit, purified by affinity chromatography

• 別名: Epidermal growth factor receptor kinase substrate 8, EPS8
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: mouse
• 化学種の反応性（ホモロジーによる予測）: human (immunogen homology), rat (based on 100% sequence homology)
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_004438
• UniProtアクセッション番号: Q12929
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... EPS8(2059)

詳細

詳細

EPS8 (epidermal growth factor receptor kinase substrate 8), which was originally identified as a substrate for the kinase activity of EGFR, is a multifunctional protein that is known to play a role in spermatogenesis, the regulation of actin, and other cellular processes. EPS8 uses its SH3 domain to complex with Abi1 and SOS1, leading to Rac activation and subsequent actin cytoskeletal remodeling. In the same manner, it binds with RN-tre to inhibit the internalization of EGFR. EPS8 also works with Arp3 to modulate actin dynamics within the seminiferous epithelium at the apical ES and the BTB.

免疫原

KLH-conjugated linear peptide corresponding to human EPS8.

アプリケーション

Research Category
アポトーシス及び癌

Research Sub Category
アポトーシス-追加

This EPS8 antibody is validated for use in WB for the detection of the EPS8 protein.

品質

Evaluated by Western Blot in NIH/3T3 cell lysate.

Western Blot Analysis: 0.2 µg/mL of this antibody detected EPS8 in 10 µg of NIH/3T3 cell lysate.

ターゲットの説明

~97 kDa observed. A second isoform is known to exist at ~68 kDa Uncharacterized bands may be observed at ~50 kDa and ~37 kDa in some cell lysates.

物理的形状

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
NIH/3T3 cell lysate

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable